SIRT6 sirtuin 6 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: SIRT6provided by VGNC
Official Full Name: sirtuin 6provided by VGNC
Primary source: VGNC:VGNC:34635
See related: BGD:BT19067; Ensembl:ENSBTAG00000019909
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (19856994..19865253)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT6 cooperated with SIRT5 to decrease lipid deposition in bovine preadipocytes.
Title: SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKα signaling pathway.
the underlying mechanism of methylation and transcription regulation of SIRT6 expression in bovine adipocytes
Title: Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS) and management in beef cattle breeding programs.
Title: Sequence variants in the bovine silent information regulator 6, their linkage and their associations with body measurements and carcass quality traits in Qinchuan cattle.

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General gene information

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Markers

MARC_4097-4098:996679378:1 (e-PCR)
- UniSTS:269323

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacylase sirtuin-6

NP_001091553.1

EC 2.4.2.31

XP_010805287.1

EC 2.4.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098084.1 → NP_001091553.1 NAD-dependent protein deacylase sirtuin-6

See identical proteins and their annotated locations for NP_001091553.1

Status: PROVISIONAL

Source sequence(s)

BC140592

UniProtKB/TrEMBL

A5D7K6, F1N1P9

Related

ENSBTAP00000102039.1, ENSBTAT00000087850.1

Conserved Domains (1) summary

cd01410
Location:45 → 257

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

Range

19856994..19865253

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010806985.4 → XP_010805287.1 NAD-dependent protein deacylase sirtuin-6 isoform X1

Conserved Domains (1) summary

cl00195
Location:11 → 203

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...