U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mapkapk5 MAPK activated protein kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498183, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mapkapk5provided by RGD
Official Full Name
MAPK activated protein kinase 5provided by RGD
Primary source
RGD:1564113
See related
Ensembl:ENSRNOG00000001345 AllianceGenome:RGD:1564113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including calmodulin binding activity; p53 binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of DNA metabolic process; protein phosphorylation; and stress-induced premature senescence. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in cytosol; nucleoplasm; and septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 227.4), Thymus (RPKM 164.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mapkapk5 in Genome Data Viewer
Location:
12q16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40654220..40673740)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34993520..35013059)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40510378..40529332)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family, member 10 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene ADAM metallopeptidase domain 1a Neighboring gene transmembrane protein 116 Neighboring gene a disintegrin and metallopeptidase domain 1b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor. Kostenko S, et al. Cell Mol Life Sci, 2011 Jan. PMID 20640477, Free PMC Article
  2. The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Kress TR, et al. Mol Cell, 2011 Feb 18. PMID 21329882
  3. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. Kostenko S, et al. Cell Signal, 2009 May. PMID 19166925
  4. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. Seternes OM, et al. EMBO J, 2004 Dec 8. PMID 15577943, Free PMC Article
  5. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. Kant S, et al. J Biol Chem, 2006 Nov 17. PMID 16973613

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC116327

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in septin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
MAP kinase-activated protein kinase 5
Names
mitogen-activated protein kinase-activated protein kinase 5
NP_001020932.2
NP_001157515.1
XP_038945629.1
XP_038945631.1
XP_038945632.1
XP_063127655.1
XP_063127656.1
XP_063127657.1
XP_063127658.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025761.2 → NP_001020932.2  MAP kinase-activated protein kinase 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI715466, BC099161
    UniProtKB/TrEMBL
    Q4KLJ9
    Conserved Domains (2) summary
    smart00220
    Location:1 → 203
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 203
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001164043.1 → NP_001157515.1  MAP kinase-activated protein kinase 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI715466, BC099161, FM032487
    UniProtKB/TrEMBL
    F1LN87
    Related
    ENSRNOP00000001817.5, ENSRNOT00000001817.8
    Conserved Domains (2) summary
    smart00220
    Location:26 → 304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15 → 304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    40654220..40673740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089701.2 → XP_038945629.1  MAP kinase-activated protein kinase 5 isoform X5

    UniProtKB/TrEMBL
    F1LN87
    Conserved Domains (1) summary
    cd14171
    Location:15 → 304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

  2. XM_063271588.1 → XP_063127658.1  MAP kinase-activated protein kinase 5 isoform X6

  3. XM_063271585.1 → XP_063127655.1  MAP kinase-activated protein kinase 5 isoform X2

  4. XM_039089703.2 → XP_038945631.1  MAP kinase-activated protein kinase 5 isoform X1

    UniProtKB/TrEMBL
    F7FFP2, Q4KLJ9
    Related
    ENSRNOP00000061902.3
    Conserved Domains (1) summary
    cl21453
    Location:13 → 155
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039089704.2 → XP_038945632.1  MAP kinase-activated protein kinase 5 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 124
    PKc_like; Protein Kinases, catalytic domain

  6. XM_063271587.1 → XP_063127657.1  MAP kinase-activated protein kinase 5 isoform X4

  7. XM_063271586.1 → XP_063127656.1  MAP kinase-activated protein kinase 5 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous