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AMOTL2 angiomotin like 2 [ Canis lupus familiaris (dog) ]

Gene ID: 485669, updated on 17-Aug-2024

Summary

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Official Symbol
AMOTL2provided by VGNC
Official Full Name
angiomotin like 2provided by VGNC
Primary source
VGNC:VGNC:37837
See related
Ensembl:ENSCAFG00845030294
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (31663168..31680819, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (31125977..31143625, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (31666646..31684285, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (31360413..31378048, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (31418995..31436602, complement)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119865309 Neighboring gene receptor like tyrosine kinase Neighboring gene 60S ribosomal protein L7a-like Neighboring gene anaphase promoting complex subunit 13 Neighboring gene centrosomal protein 63

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Zhao B, et al. Genes Dev, 2011 Jan 1. PMID 21205866, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of cell polarity involved in ameboidal cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
angiomotin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    31663168..31680819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432393.1 → XP_038288321.1  angiomotin-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TKL6, A0A8I3QA39, A0A8P0SC30
    Related
    ENSCAFP00845042250.1, ENSCAFT00845053762.1
    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal

  2. XM_038432392.1 → XP_038288320.1  angiomotin-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LV93, A0A8C0TKL6
    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    31360413..31378048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038507692.1 → XP_038363620.1  angiomotin-like protein 2 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal

  2. XM_038507691.1 → XP_038363619.1  angiomotin-like protein 2 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    31418995..31436602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635125.1 → XP_038491053.1  angiomotin-like protein 2 isoform X2

  2. XM_038635124.1 → XP_038491052.1  angiomotin-like protein 2 isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    31666646..31684285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038570932.1 → XP_038426860.1  angiomotin-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TKL6, A0A8I3QA39, A0A8P0SC30
    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal

  2. XM_038570931.1 → XP_038426859.1  angiomotin-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LV93, A0A8C0TKL6
    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    31125977..31143625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014106722.3 → XP_013962197.1  angiomotin-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TKL6, A0A8I3QA39, A0A8P0SC30
    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal

  2. XM_542789.7 → XP_542789.3  angiomotin-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LV93, A0A8C0TKL6
    Conserved Domains (2) summary
    COG1196
    Location:296 → 579
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:482 → 682
    Angiomotin_C; Angiomotin C terminal
Nucleotide Protein
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