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CCN2 cellular communication network factor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 476202, updated on 17-Aug-2024

Summary

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Official Symbol
CCN2provided by VGNC
Official Full Name
cellular communication network factor 2provided by VGNC
Primary source
VGNC:VGNC:39696
See related
Ensembl:ENSCAFG00845004492
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
CTGF
Orthologs
human mouse all
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Genomic context

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See CCN2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (24930014..24932944, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (26004899..26007816, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (25137679..25140601, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (24975729..24978649, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (24865809..24868736, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene uncharacterized LOC119870728 Neighboring gene uncharacterized LOC119870645 Neighboring gene uncharacterized LOC119870729 Neighboring gene uncharacterized LOC102156553 Neighboring gene tubulin alpha-1A chain-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models. Wu CK, et al. Eur J Heart Fail, 2014 Feb. PMID 24464932
  2. miR‑132 in atrial fibrillation directly targets connective tissue growth factor. Qiao G, et al. Mol Med Rep, 2017 Oct. PMID 28731126

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR132 may target CTGF in regulating fibrosis in Ang IItreated cardiac fibroblasts.
    Title: miR‑132 in atrial fibrillation directly targets connective tissue growth factor.
  2. In a canine model of diastolic dysfunction, myocardial CTGF expression increased after aortic banding.
    Title: Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CCN family member 2
Names
connective tissue growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    24930014..24932944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038654148.1 → XP_038510076.1  CCN family member 2

    UniProtKB/TrEMBL
    A0A8C0RBZ9, A0A8I3MT25
    Related
    ENSCAFP00845006323.1, ENSCAFT00845008039.1
    Conserved Domains (4) summary
    smart00214
    Location:103 → 162
    VWC; von Willebrand factor (vWF) type C domain
    pfam00007
    Location:253 → 345
    Cys_knot; Cystine-knot domain
    pfam00219
    Location:49 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:199 → 242
    TSP1_CCN; CCN3 Nov like TSP1 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    24975729..24978649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038465415.1 → XP_038321343.1  CCN family member 2

    Conserved Domains (4) summary
    smart00214
    Location:103 → 162
    VWC; von Willebrand factor (vWF) type C domain
    pfam00007
    Location:253 → 345
    Cys_knot; Cystine-knot domain
    pfam00219
    Location:49 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:199 → 242
    TSP1_CCN; CCN3 Nov like TSP1 domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    24865809..24868736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038590331.1 → XP_038446259.1  CCN family member 2

    Conserved Domains (4) summary
    smart00214
    Location:103 → 162
    VWC; von Willebrand factor (vWF) type C domain
    pfam00007
    Location:253 → 345
    Cys_knot; Cystine-knot domain
    pfam00219
    Location:49 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:199 → 242
    TSP1_CCN; CCN3 Nov like TSP1 domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    25137679..25140601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038526030.1 → XP_038381958.1  CCN family member 2

    UniProtKB/TrEMBL
    A0A8C0RBZ9, A0A8I3MT25
    Conserved Domains (4) summary
    smart00214
    Location:103 → 162
    VWC; von Willebrand factor (vWF) type C domain
    pfam00007
    Location:253 → 345
    Cys_knot; Cystine-knot domain
    pfam00219
    Location:49 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:199 → 242
    TSP1_CCN; CCN3 Nov like TSP1 domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26004899..26007816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003638769.5 → XP_003638817.1  CCN family member 2

    UniProtKB/TrEMBL
    A0A8C0RBZ9, A0A8I3MT25
    Conserved Domains (4) summary
    smart00214
    Location:103 → 162
    VWC; von Willebrand factor (vWF) type C domain
    pfam00007
    Location:253 → 345
    Cys_knot; Cystine-knot domain
    pfam00219
    Location:49 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:199 → 242
    TSP1_CCN; CCN3 Nov like TSP1 domain
Nucleotide Protein
Heading Accession and Version

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