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AGO2 argonaute RISC catalytic component 2 [ Canis lupus familiaris (dog) ]

Gene ID: 475107, updated on 17-Aug-2024

Summary

Official Symbol
AGO2provided by VGNC
Official Full Name
argonaute RISC catalytic component 2provided by VGNC
Primary source
VGNC:VGNC:37707
See related
Ensembl:ENSCAFG00845012184
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
EIF2C2
Orthologs
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Genomic context

Location:
chromosome: 13
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (35564998..35666115, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (35028442..35140440, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (35795131..35895912, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (35274354..35386196, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (35364327..35476164, complement)

Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098573 Neighboring gene uncharacterized LOC111098574 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene uncharacterized LOC111098575 Neighboring gene uncharacterized LOC119864475

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables endoribonuclease activity, cleaving siRNA-paired mRNA IEA
Inferred from Electronic Annotation
more info
PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
protein argonaute-2
Names
argonaute 2, RISC catalytic component
eukaryotic translation initiation factor 2C, 2
XP_022282463.1
XP_038284963.1
XP_038284971.1
XP_038349285.1
XP_038349286.1
XP_038349287.1
XP_038411533.1
XP_038411534.1
XP_038411535.1
XP_038475437.1
XP_038475438.1
XP_038475439.1
XP_038541044.1
XP_038541045.1
XP_038541046.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051817.1 Reference ROS_Cfam_1.0

    Range
    35564998..35666115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038685116.1XP_038541044.1  protein argonaute-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KQV6, A0A8C0KR21
    Related
    ENSCAFP00845017034.1, ENSCAFT00845021667.1
    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:93167
    ArgoN; N-terminal domain of argonaute
  2. XM_038685117.1XP_038541045.1  protein argonaute-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KR21
    Related
    ENSCAFP00845017065.1, ENSCAFT00845021702.1
    Conserved Domains (4) summary
    cd02846
    Location:221341
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:386811
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:170220
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:86160
    ArgoN; N-terminal domain of argonaute
  3. XM_038685118.1XP_038541046.1  protein argonaute-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QHQ0
    Conserved Domains (4) summary
    cd02846
    Location:150270
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:315740
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:99149
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:1589
    ArgoN; N-terminal domain of argonaute

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049273.1 Alternate UMICH_Zoey_3.1

    Range
    35274354..35386196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038493357.1XP_038349285.1  protein argonaute-2 isoform X1

    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:93167
    ArgoN; N-terminal domain of argonaute
  2. XM_038493358.1XP_038349286.1  protein argonaute-2 isoform X2

    Conserved Domains (4) summary
    cd02846
    Location:221341
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:386811
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:170220
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:86160
    ArgoN; N-terminal domain of argonaute
  3. XM_038493359.1XP_038349287.1  protein argonaute-2 isoform X3

    Conserved Domains (4) summary
    cd02846
    Location:150270
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:315740
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:99149
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:1589
    ArgoN; N-terminal domain of argonaute

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

    Range
    35364327..35476164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038619509.1XP_038475437.1  protein argonaute-2 isoform X1

    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:93167
    ArgoN; N-terminal domain of argonaute
  2. XM_038619510.1XP_038475438.1  protein argonaute-2 isoform X2

    Conserved Domains (4) summary
    cd02846
    Location:221341
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:386811
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:170220
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:86160
    ArgoN; N-terminal domain of argonaute
  3. XM_038619511.1XP_038475439.1  protein argonaute-2 isoform X3

    Conserved Domains (4) summary
    cd02846
    Location:150270
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:315740
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:99149
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:1589
    ArgoN; N-terminal domain of argonaute

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

    Range
    35795131..35895912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038555605.1XP_038411533.1  protein argonaute-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KQV6, A0A8C0KR21
    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:93167
    ArgoN; N-terminal domain of argonaute
  2. XM_038555606.1XP_038411534.1  protein argonaute-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KR21
    Conserved Domains (4) summary
    cd02846
    Location:221341
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:386811
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:170220
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:86160
    ArgoN; N-terminal domain of argonaute
  3. XM_038555607.1XP_038411535.1  protein argonaute-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QHQ0
    Conserved Domains (4) summary
    cd02846
    Location:150270
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:315740
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:99149
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:1589
    ArgoN; N-terminal domain of argonaute

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35028442..35140440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429035.1XP_038284963.1  protein argonaute-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KQV6, A0A8C0KR21
    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:93167
    ArgoN; N-terminal domain of argonaute
  2. XM_038429043.1XP_038284971.1  protein argonaute-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KR21
    Conserved Domains (4) summary
    cd02846
    Location:221341
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:386811
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:170220
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:86160
    ArgoN; N-terminal domain of argonaute
  3. XM_022426755.2XP_022282463.1  protein argonaute-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QHQ0
    Conserved Domains (4) summary
    cd02846
    Location:150270
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:315740
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:99149
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:1589
    ArgoN; N-terminal domain of argonaute