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Ago2 argonaute RISC catalytic subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 239528, updated on 5-Jan-2023

Summary

Official Symbol
Ago2provided by MGI
Official Full Name
argonaute RISC catalytic subunit 2provided by MGI
Primary source
MGI:MGI:2446632
See related
Ensembl:ENSMUSG00000036698 AllianceGenome:MGI:2446632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif2c2; Gerp95; Gm10365; mKIAA4215; 1110029L17Rik; 2310051F07Rik
Summary
Enables endoribonuclease activity; mRNA binding activity; and miRNA binding activity. Involved in regulation of gene expression. Acts upstream of or within RNA metabolic process; positive regulation of gene expression; and post-embryonic development. Located in several cellular components, including P-body; cytosol; and dendrite. Part of RISC complex and RISC-loading complex. Is expressed in several structures, including central nervous system; early embryo; lung; sensory organ; and tooth. Orthologous to human AGO2 (argonaute RISC catalytic component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 19.6), spleen adult (RPKM 13.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ago2 in Genome Data Viewer
Location:
15; 15 D3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (72973474..73056796, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (73101625..73184947, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 9 Neighboring gene VISTA enhancer mm1679 Neighboring gene chromatin accessibility complex 1 Neighboring gene predicted gene, 31725 Neighboring gene PTK2 protein tyrosine kinase 2 Neighboring gene microRNA 151 Neighboring gene predicted gene, 41344

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4215

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endoribonuclease activity, cleaving miRNA-paired mRNA ISO
Inferred from Sequence Orthology
more info
 
enables endoribonuclease activity, cleaving siRNA-paired mRNA ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA cap binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables miRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to siRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables siRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RISC complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA secondary structure unwinding ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within miRNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid precursor protein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in siRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in siRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
 
part_of RISC-loading complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC-loading complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
part_of mRNA cap binding complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of polysome ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein argonaute-2
Names
Piwi/Argonaute family protein meIF2C2
argonaute 2
argonaute RISC catalytic component 2
eukaryotic translation initiation factor 2C, 2
NP_694818.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153178.5NP_694818.3  protein argonaute-2

    See identical proteins and their annotated locations for NP_694818.3

    Status: VALIDATED

    Source sequence(s)
    AC118640, AC161581
    Consensus CDS
    CCDS37098.1
    UniProtKB/Swiss-Prot
    Q571J6, Q8CJG0
    UniProtKB/TrEMBL
    A0A6P5R563, Q3UQ34
    Related
    ENSMUSP00000042207.10, ENSMUST00000044113.12
    Conserved Domains (2) summary
    PLN03202
    Location:7859
    PLN03202; protein argonaute; Provisional
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    72973474..73056796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)