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jdp2b Jun dimerization protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 436766, updated on 12-Sep-2024

Summary

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Official Symbol
jdp2bprovided by ZNC
Official Full Name
Jun dimerization protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-197
See related
Ensembl:ENSDARG00000020133 AllianceGenome:ZFIN:ZDB-GENE-040718-197
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
jdp2; fk87c02; zgc:92851; wu:fk87c02
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of histone deacetylation and regulation of transcription, DNA-templated. Predicted to be active in nucleus. Orthologous to human JDP2 (Jun dimerization protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (46586687..46594691)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (46682967..46690971)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-153j24.3 Neighboring gene v-fos FBJ murine osteosarcoma viral oncogene homolog Ab Neighboring gene basic leucine zipper transcription factor, ATF-like Neighboring gene adenylate cyclase 3b Neighboring gene WD repeat domain 26b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nuclear translocation of doublecortin-like protein kinase and phosphorylation of a transcription factor JDP2. Nagamine T, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24582561
  2. Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88. Koch BEV, et al. Nat Commun, 2018 Oct 5. PMID 30291253, Free PMC Article
  3. New reporter zebrafish line unveils heterogeneity among lymphatic endothelial cells during development. Frétaud M, et al. Dev Dyn, 2021 May. PMID 33369805
  4. Acute exposure to ustiloxin A affects growth and development of early life zebrafish, Danio rerio. Hu Z, et al. Chemosphere, 2019 Jul. PMID 30978596
  5. Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2. Baik J, et al. Nat Commun, 2016 Oct 7. PMID 27713415, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies establish JDP2 as a novel oncogene in high-risk T cell acute lymphoblastic leukemia.
    Title: JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
  2. The authors identify Jdp2 as a key endoglin-dependent Wnt target, sufficient to establish haematopoietic fate in early mesoderm when BMP and Wnt crosstalk is disturbed.
    Title: Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2.
  3. the kinase fragment of DCLK is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
    Title: Nuclear translocation of doublecortin-like protein kinase and phosphorylation of a transcription factor JDP2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
jun dimerization protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002493.1 → NP_001002493.1  jun dimerization protein 2

    See identical proteins and their annotated locations for NP_001002493.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076313
    UniProtKB/Swiss-Prot
    Q6DGM8
    Related
    ENSDARP00000010866.4, ENSDART00000014166.6
    Conserved Domains (1) summary
    cd14722
    Location:80 → 133
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    46586687..46594691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160857.4 → XP_005160914.1  jun dimerization protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005160914.1

    UniProtKB/Swiss-Prot
    Q6DGM8
    Related
    ENSDARP00000144615.1, ENSDART00000179266.2
    Conserved Domains (1) summary
    cd14722
    Location:80 → 133
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DGM8.1 GenPept UniProtKB/Swiss-Prot:Q6DGM8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.