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    REN renin [ Canis lupus familiaris ]

    Gene ID: 403838, updated on 4-Feb-2012
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    Summary

    Gene symbol
    REN
    Gene description
    renin
    See related
    Ensembl:ENSCAFG00000009623
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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    Genomic context

    Location :
    chromosome: 38
    Sequence :
    Chromosome: 38; NC_006620.3 (744730..755012, complement)
    See REN in MapViewer

    Chromosome 38 - NC_006620.3Genomic Context describing neighboring genes Neighboring gene SRY (sex determining region Y)-box 13 Neighboring gene ethanolamine kinase 2 Neighboring gene golgi transport 1A Neighboring gene pleckstrin homology domain containing, family A member 6

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Role of the renin-angiotensin-aldosterone system for control of arterial blood pressure following moderate deficit in total body sodium: balance studies in freely moving dogs. Seeliger E, et al. Clin Exp Pharmacol Physiol, 2010 Feb. PMID 19930429.
    2. Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade. Bie P, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Feb. PMID 19073902.
    3. Cloning, characterization and site-directed mutagenesis of canine renin. Bukhtiyarov Y, et al. J Biochem, 2007 Dec. PMID 17942478.
    4. Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: a comprehensive study of all its components in the dog. Lee YA, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855304.

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. With a moderate deficit in total body sodium and total body water, the renin-angiotensin-aldosterone system is the major factor controlling arterial blood pressure.
      Title: Role of the renin-angiotensin-aldosterone system for control of arterial blood pressure following moderate deficit in total body sodium: balance studies in freely moving dogs.
    2. Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta1-receptor blockade.
      Title: Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade.
    3. Characterization of canine renin with mutations in the substrate binding site.
      Title: Cloning, characterization and site-directed mutagenesis of canine renin.
    Submit: New GeneRIF Correction
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    General gene information

    Genotypes

    Homology

    • Homologs of the REN gene: The REN gene is conserved in human, chimpanzee, , cow, mouse, rat, chicken, zebrafish, fruit fly, and P.falciparum.

    Pathways from BioSystems

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    General protein information

    Preferred Names
    renin
    Names
    renin
    angiotensinogenase
    NP_001003194.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003194.1 → NP_001003194.1  renin precursor

      Status: PROVISIONAL

      Source sequence(s)
      AY630442
      UniProtKB/Swiss-Prot
      Q6DYE7
      Related
      ENSCAFP00000033421, ENSCAFT00000037807
      Conserved Domains (3) summary
      pfam07966
      Location:30 – 53
      Blast Score: 95
      A1_Propeptide; A1 Propeptide
      cd05487
      Location:77 – 402
      Blast Score: 1611
      renin_like; Renin stimulates production of angiotensin and thus affects blood pressure.
      pfam00026
      Location:84 – 402
      Blast Score: 1061
      Asp; Eukaryotic aspartyl protease

    RefSeqs of Annotated Genomes: Build 3.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006620.3 Reference CanFam3.1 Primary Assembly

      Range
      744730..755012, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY630442.1 AAT68959.1
    mRNA U67198.1 AAC48636.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DYE7.1 GenPept UniProtKB/Swiss-Prot:Q6DYE7
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    Additional Links

    Gene LinkOut

      Supplemental Content