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picalma phosphatidylinositol binding clathrin assembly protein a [ Danio rerio (zebrafish) ]

Gene ID: 393901, updated on 17-Sep-2024

Summary

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Official Symbol
picalmaprovided by ZNC
Official Full Name
phosphatidylinositol binding clathrin assembly protein aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-761
See related
Ensembl:ENSDARG00000012866 AllianceGenome:ZFIN:ZDB-GENE-040426-761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
picalm; zgc:55615
Summary
Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to act upstream of or within clathrin coat assembly and endocytosis. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See picalma in Genome Data Viewer
Location:
chromosome: 10
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (29137999..29225165)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (29251181..29338540)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:ch211-103f14.3 Neighboring gene zona pellucida-like domain containing 1a Neighboring gene coiled-coil domain containing 83 Neighboring gene synaptotagmin-like 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55615

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol binding clathrin assembly protein a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365260.1 → NP_001352189.1  phosphatidylinositol binding clathrin assembly protein a isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX005332
    UniProtKB/TrEMBL
    Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  2. NM_001365261.1 → NP_001352190.1  phosphatidylinositol binding clathrin assembly protein a isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX005332
    UniProtKB/TrEMBL
    A0A8M9QKL4, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain

  3. NM_200927.2 → NP_957221.2  phosphatidylinositol binding clathrin assembly protein a isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX005332
    UniProtKB/TrEMBL
    A0A8M3AWT7, F1QKW9, Q7ZVU6
    Related
    ENSDARP00000021165.8, ENSDART00000025227.11
    Conserved Domains (2) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain
    pfam12287
    Location:337 → 436
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    29137999..29225165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479128.2 → XP_021334803.1  phosphatidylinositol binding clathrin assembly protein a isoform X8

    UniProtKB/TrEMBL
    A0A8M9Q5T8, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  2. XM_009305379.4 → XP_009303654.1  phosphatidylinositol binding clathrin assembly protein a isoform X10

    UniProtKB/TrEMBL
    A0A8M3B3B4, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain

  3. XM_068223744.1 → XP_068079845.1  phosphatidylinositol binding clathrin assembly protein a isoform X11

  4. XM_068223745.1 → XP_068079846.1  phosphatidylinositol binding clathrin assembly protein a isoform X12

  5. XM_068223749.1 → XP_068079850.1  phosphatidylinositol binding clathrin assembly protein a isoform X25

  6. XM_068223752.1 → XP_068079853.1  phosphatidylinositol binding clathrin assembly protein a isoform X28

  7. XM_068223750.1 → XP_068079851.1  phosphatidylinositol binding clathrin assembly protein a isoform X26

    Related
    ENSDARP00000144639.2, ENSDART00000178280.2

  8. XM_021479135.2 → XP_021334810.1  phosphatidylinositol binding clathrin assembly protein a isoform X19

    UniProtKB/TrEMBL
    A0A8M9QKL4, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain

  9. XM_068223751.1 → XP_068079852.1  phosphatidylinositol binding clathrin assembly protein a isoform X27

  10. XM_009305389.4 → XP_009303664.1  phosphatidylinositol binding clathrin assembly protein a isoform X29

    UniProtKB/TrEMBL
    A0A8M3AWT7, F1QKW9, Q7ZVU6
    Conserved Domains (2) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain
    pfam12287
    Location:337 → 436
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

  11. XM_021479138.2 → XP_021334813.1  phosphatidylinositol binding clathrin assembly protein a isoform X30

    UniProtKB/TrEMBL
    A0A8M9Q5U3
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain

  12. XM_009305392.4 → XP_009303667.1  phosphatidylinositol binding clathrin assembly protein a isoform X31

    UniProtKB/TrEMBL
    A0A8M3B3B6, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 282
    ANTH; ANTH domain

  13. XM_068223753.1 → XP_068079854.1  phosphatidylinositol binding clathrin assembly protein a isoform X32

  14. XM_021479123.2 → XP_021334798.1  phosphatidylinositol binding clathrin assembly protein a isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q5T5
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  15. XM_009305372.4 → XP_009303647.1  phosphatidylinositol binding clathrin assembly protein a isoform X4

    UniProtKB/TrEMBL
    A0A8M3AWV7
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain

  16. XM_021479126.2 → XP_021334801.1  phosphatidylinositol binding clathrin assembly protein a isoform X3

    UniProtKB/TrEMBL
    A0A8M9QGF6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  17. XM_009305375.4 → XP_009303650.1  phosphatidylinositol binding clathrin assembly protein a isoform X6

    UniProtKB/TrEMBL
    A0A8M3AWT2, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain

  18. XM_021479127.2 → XP_021334802.1  phosphatidylinositol binding clathrin assembly protein a isoform X5

    UniProtKB/TrEMBL
    A0A8M9PTF3
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  19. XM_009305376.4 → XP_009303651.1  phosphatidylinositol binding clathrin assembly protein a isoform X7

    UniProtKB/TrEMBL
    A0A8M3B694, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 286
    ANTH; ANTH domain

  20. XM_021479129.2 → XP_021334804.1  phosphatidylinositol binding clathrin assembly protein a isoform X9

    UniProtKB/TrEMBL
    A0A8M9QBW5, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  21. XM_021479130.2 → XP_021334805.1  phosphatidylinositol binding clathrin assembly protein a isoform X13

    UniProtKB/TrEMBL
    A0A8M9QKL0, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  22. XM_068223746.1 → XP_068079847.1  phosphatidylinositol binding clathrin assembly protein a isoform X14

  23. XM_021479132.2 → XP_021334807.1  phosphatidylinositol binding clathrin assembly protein a isoform X15

    UniProtKB/TrEMBL
    A0A8M9PTF8, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  24. XM_068223747.1 → XP_068079848.1  phosphatidylinositol binding clathrin assembly protein a isoform X18

  25. XM_021479134.2 → XP_021334809.1  phosphatidylinositol binding clathrin assembly protein a isoform X17

    UniProtKB/TrEMBL
    A0A8M9QBX0, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain

  26. XM_021479136.2 → XP_021334811.1  phosphatidylinositol binding clathrin assembly protein a isoform X20

    UniProtKB/TrEMBL
    A0A8M9QGG5, Q7ZVU6
    Conserved Domains (2) summary
    pfam07651
    Location:24 → 286
    ANTH; ANTH domain
    pfam12287
    Location:341 → 440
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

  27. XM_021479125.2 → XP_021334800.1  phosphatidylinositol binding clathrin assembly protein a isoform X2

    UniProtKB/TrEMBL
    A0A8M9QKK5
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain

  28. XM_021479133.2 → XP_021334808.1  phosphatidylinositol binding clathrin assembly protein a isoform X16

    UniProtKB/TrEMBL
    A0A8M9Q5U0, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain

  29. XM_068223748.1 → XP_068079849.1  phosphatidylinositol binding clathrin assembly protein a isoform X21

  30. XM_009305387.4 → XP_009303662.1  phosphatidylinositol binding clathrin assembly protein a isoform X23

    UniProtKB/TrEMBL
    A0A8M3AWV9, Q7ZVU6
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 282
    ANTH; ANTH domain

  31. XM_021479137.2 → XP_021334812.1  phosphatidylinositol binding clathrin assembly protein a isoform X22

    UniProtKB/TrEMBL
    A0A8M9PTG3, Q7ZVU6
    Conserved Domains (2) summary
    pfam07651
    Location:24 → 282
    ANTH; ANTH domain
    pfam12287
    Location:337 → 436
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

  32. XM_009305388.4 → XP_009303663.1  phosphatidylinositol binding clathrin assembly protein a isoform X24

    UniProtKB/TrEMBL
    A0A8M3BD23, Q7ZVU6
    Related
    ENSDARP00000032600.7, ENSDART00000034242.9
    Conserved Domains (1) summary
    pfam07651
    Location:19 → 282
    ANTH; ANTH domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394790.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    149300..238526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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