actr10 actin related protein 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: actr10provided by ZNC
Official Full Name: actin related protein 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-768
See related: Ensembl:ENSDARG00000038432 AllianceGenome:ZFIN:ZDB-GENE-040426-768
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55635
Summary: Acts upstream of or within central nervous system myelin formation and retrograde axonal transport of mitochondrion. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of dynactin complex. Is expressed in brain and posterior lateral line ganglion. Orthologous to human ACTR10 (actin related protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (54274431..54286860)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (54404860..54417289)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Actr10 role in MBP mRNA localization in oligodendrocytes.
Title: Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.
Together, this work identifies Actr10 as a factor necessary for dynactin-mitochondria interaction, enhancing our understanding of how mitochondria properly localize in axons.
Title: Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system myelin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal transport of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retrograde axonal transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
part_of dynactin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin-related protein 10

Names: ARP10 actin related protein 10 homolog; actin-related protein 10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200170.1 → NP_956464.1 actin-related protein 10

See identical proteins and their annotated locations for NP_956464.1

Status: PROVISIONAL

Source sequence(s)

BC045412

UniProtKB/TrEMBL

Q7ZVU0

Related

ENSDARP00000090111.3, ENSDART00000099338.6

Conserved Domains (2) summary

smart00268
Location:13 → 362

ACTIN; Actin

cl17037
Location:12 → 362

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily