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fem1c fem-1 homolog c [ Danio rerio (zebrafish) ]

Gene ID: 378965, updated on 18-Sep-2024

Summary

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Official Symbol
fem1cprovided by ZNC
Official Full Name
fem-1 homolog cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031008-3
See related
Ensembl:ENSDARG00000102147 AllianceGenome:ZFIN:ZDB-GENE-031008-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Orthologous to human FEM1C (fem-1 homolog C). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (423393..425258, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (423393..425258, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 36 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene si:ch211-87m7.1 Neighboring gene protein geranylgeranyltransferase type I, beta subunit Neighboring gene solute carrier family 12 member 2-like Neighboring gene GRAM domain containing 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. Ventura-Holman T, et al. Gene, 2003 Sep 18. PMID 14527725
  2. Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. Sullivan C, et al. PLoS One, 2017. PMID 28658311, Free PMC Article
  3. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein fem-1 homolog C
Names
FEM1-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198145.2 → NP_937788.2  protein fem-1 homolog C

    See identical proteins and their annotated locations for NP_937788.2

    Status: PROVISIONAL

    Source sequence(s)
    BC056774
    UniProtKB/Swiss-Prot
    Q6PGZ5, Q7T3P8
    Related
    ENSDARP00000136244.1, ENSDART00000168496.1
    Conserved Domains (4) summary
    cd00204
    Location:82 → 202
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:87 → 178
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:182 → 233
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118 → 146
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    423393..425258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T3P8.2 GenPept UniProtKB/Swiss-Prot:Q7T3P8

Gene LinkOut

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