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FEM1C fem-1 homolog C [ Homo sapiens (human) ]

Gene ID: 56929, updated on 5-Aug-2022

Summary

Official Symbol
FEM1Cprovided by HGNC
Official Full Name
fem-1 homolog Cprovided by HGNC
Primary source
HGNC:HGNC:16933
See related
Ensembl:ENSG00000145780 MIM:608767; AllianceGenome:HGNC:16933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEM1A; EUROIMAGE686608; EUROIMAGE783647
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 24.9), testis (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

See FEM1C in Genome Data Viewer
Location:
5q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115520908..115544775, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116033707..116057577, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114856605..114880472, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene COX assembly mitochondrial protein homolog Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 5951 Neighboring gene TMED7-TICAM2 readthrough Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene TICAM2 antisense RNA 1 Neighboring gene transmembrane p24 trafficking protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein fem-1 homolog C
Names
FEM1-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020177.3NP_064562.1  protein fem-1 homolog C

    See identical proteins and their annotated locations for NP_064562.1

    Status: VALIDATED

    Source sequence(s)
    AB058688, AC008628, BC028369, W07603
    Consensus CDS
    CCDS4118.1
    UniProtKB/Swiss-Prot
    Q96JP0, Q9NPL9
    Related
    ENSP00000274457.3, ENST00000274457.5
    Conserved Domains (4) summary
    PHA02876
    Location:164568
    PHA02876; ankyrin repeat protein; Provisional
    COG0666
    Location:462599
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:118146
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:87178
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115520908..115544775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    116033707..116057577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)