lpar1 lysophosphatidic acid receptor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lpar1provided by ZNC
Official Full Name: lysophosphatidic acid receptor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-499
See related: Ensembl:ENSDARG00000099840 AllianceGenome:ZFIN:ZDB-GENE-030616-499
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: edg2; zgc:92157; si:dz46m7.1; si:dz22b13.1
Summary: Enables lysophosphatidic acid receptor activity. Acts upstream of or within cartilage development; hemangioblast cell differentiation; and vasculature development. Predicted to be located in cell surface; endosome; and membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (13000704..13064111)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (13042575..13105992)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the ATX-LPA-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates
Title: Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.
LPA(1) is necessary for lymphatic vessel formation during embryonic development in zebrafish.
Title: LPA1 is essential for lymphatic vessel development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophosphatidic acid receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemangioblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 1

Names: endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; lpa1; zlpa1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.