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Kat14 lysine acetyltransferase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362224, updated on 13-Apr-2024

Summary

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Official Symbol
Kat14provided by RGD
Official Full Name
lysine acetyltransferase 14provided by RGD
Primary source
RGD:1309538
See related
Ensembl:ENSRNOG00000007160 AllianceGenome:RGD:1309538
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Csrp2bp
Summary
Predicted to enable histone acetyltransferase activity. Predicted to be involved in histone H3 acetylation. Predicted to act upstream of or within G2/M transition of mitotic cell cycle and histone acetylation. Predicted to be located in nucleus. Predicted to be part of ATAC complex. Orthologous to human KAT14 (lysine acetyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 107.8), Thymus (RPKM 67.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kat14 in Genome Data Viewer
Location:
3q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (152194560..152235048)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (131736430..131781732)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (138508899..138549437)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase 3, pseudogene 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene ovo-like zinc finger 2 Neighboring gene PET117 cytochrome c oxidase chaperone Neighboring gene uncharacterized LOC134486459 Neighboring gene zinc finger protein 133 Neighboring gene double zinc ribbon and ankyrin repeat domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). Weiskirchen R, et al. Biochem Biophys Res Commun, 2000 Aug 11. PMID 10924333
  2. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
  3. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
  4. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
  5. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine-rich protein 2-binding protein
Names
CSRP2 binding protein
cysteine and glycine-rich protein 2 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191855.1 → NP_001178784.1  cysteine-rich protein 2-binding protein

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K6P6, D3ZSX8
    Related
    ENSRNOP00000073893.2, ENSRNOT00000091529.2
    Conserved Domains (1) summary
    pfam00583
    Location:669 → 748
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    152194560..152235048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105474.2 → XP_038961402.1  cysteine-rich protein 2-binding protein isoform X1

    Conserved Domains (1) summary
    pfam00583
    Location:458 → 537
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein Strain
Heading Accession and Version

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