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KAT14 lysine acetyltransferase 14 [ Homo sapiens (human) ]

Gene ID: 57325, updated on 5-Sep-2021

Summary

Official Symbol
KAT14provided by HGNC
Official Full Name
lysine acetyltransferase 14provided by HGNC
Primary source
HGNC:HGNC:15904
See related
Ensembl:ENSG00000149474 MIM:617501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATAC2; CRP2BP; CSRP2BP; PRO1194; dJ717M23.1
Summary
CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in brain (RPKM 8.7), testis (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

See KAT14 in Genome Data Viewer
Location:
20p11.23
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (18137153..18188372)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18118507..18169031)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene 1 Neighboring gene RNA, U7 small nuclear 137 pseudogene Neighboring gene PET117 cytochrome c oxidase chaperone Neighboring gene GGCT pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 14, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables LIM domain binding NAS
Non-traceable Author Statement
more info
PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
cysteine-rich protein 2-binding protein
Names
ADA2A-containing complex subunit 2
ATAC component 2 homolog
CRP2 binding partner
CRP2 binding protein
CSRP2-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384192.3NP_001371121.2  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. This variant contains a uORF with the complete coding region for the PET117 protein.
    Source sequence(s)
    AL050321, KF459584
    Related
    ENSP00000366909.3, ENST00000377681.8
    Conserved Domains (1) summary
    pfam00583
    Location:672751
    Acetyltransf_1; Acetyltransferase (GNAT) family
  2. NM_001392069.1NP_001378998.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Related
    ENSP00000392318.2, ENST00000435364.8
    Conserved Domains (1) summary
    pfam00583
    Location:672751
    Acetyltransf_1; Acetyltransferase (GNAT) family
  3. NM_001392070.1NP_001378999.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Related
    ENSP00000504050.1, ENST00000677266.1
    Conserved Domains (1) summary
    pfam00583
    Location:672751
    Acetyltransf_1; Acetyltransferase (GNAT) family
  4. NM_001392071.1NP_001379000.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Related
    ENSP00000503109.1, ENST00000677174.1
    Conserved Domains (1) summary
    pfam00583
    Location:672751
    Acetyltransf_1; Acetyltransferase (GNAT) family
  5. NM_001392072.1NP_001379001.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:672751
    Acetyltransf_1; Acetyltransferase (GNAT) family
  6. NM_001392073.1NP_001379002.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Related
    ENSP00000504321.1, ENST00000678777.1
    Conserved Domains (1) summary
    pfam00583
    Location:671750
    Acetyltransf_1; Acetyltransferase (GNAT) family
  7. NM_001392074.1NP_001379003.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Related
    ENSP00000504748.1, ENST00000677610.1
    Conserved Domains (1) summary
    pfam00583
    Location:671750
    Acetyltransf_1; Acetyltransferase (GNAT) family
  8. NM_001392075.1NP_001379004.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:671750
    Acetyltransf_1; Acetyltransferase (GNAT) family
  9. NM_001392076.1NP_001379005.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:671750
    Acetyltransf_1; Acetyltransferase (GNAT) family
  10. NM_001392077.1NP_001379006.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:671750
    Acetyltransf_1; Acetyltransferase (GNAT) family
  11. NM_001392078.1NP_001379007.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:671750
    Acetyltransf_1; Acetyltransferase (GNAT) family
  12. NM_001392079.1NP_001379008.1  cysteine-rich protein 2-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:650729
    Acetyltransf_1; Acetyltransferase (GNAT) family
  13. NM_001392080.1NP_001379009.1  cysteine-rich protein 2-binding protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:649728
    Acetyltransf_1; Acetyltransferase (GNAT) family
  14. NM_001392081.1NP_001379010.1  cysteine-rich protein 2-binding protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Conserved Domains (1) summary
    pfam00583
    Location:643722
    Acetyltransf_1; Acetyltransferase (GNAT) family
  15. NM_020536.7NP_065397.4  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant contains a uORF which represents a portion of the coding region for the PET117 protein.
    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS13133.1
    Related
    ENSP00000503493.1, ENST00000676935.1
    Conserved Domains (1) summary
    pfam00583
    Location:672751
    Acetyltransf_1; Acetyltransferase (GNAT) family

RNA

  1. NR_028402.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Related
    ENST00000489634.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    18137153..18188372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177926.1: Suppressed sequence

    Description
    NM_177926.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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