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St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304023, updated on 3-Apr-2024

Summary

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Official Symbol
St3gal6provided by RGD
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by RGD
Primary source
RGD:1303279
See related
Ensembl:ENSRNOG00000001653 AllianceGenome:RGD:1303279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat10
Summary
Predicted to enable beta-galactoside alpha-2,3-sialyltransferase activity. Predicted to be involved in several processes, including cellular response to interleukin-6; glycolipid metabolic process; and protein glycosylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Orthologous to human ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 296.8), Kidney (RPKM 228.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St3gal6 in Genome Data Viewer
Location:
11q12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (55530120..55590950)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (42061282..42121801)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (44176518..44237119)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain-like Neighboring gene ferritin domain containing 2 Neighboring gene uncharacterized LOC108352323 Neighboring gene uncharacterized LOC120095647 Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene ribosomal protein S28 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. Okajima T, et al. J Biol Chem, 1999 Apr 23. PMID 10206952
  2. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa. Groux-Degroote S, et al. Biochem J, 2008 Feb 15. PMID 17944600
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to interleukin-6 IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-6 ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
type 2 lactosamine alpha-2,3-sialyltransferase
Names
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
ST3GalVI
sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
NP_997485.2
XP_006248271.1
XP_006248272.1
XP_038944312.1
XP_038944314.1
XP_038944315.1
XP_038944316.1
XP_038944317.1
XP_063126635.1
XP_063126636.1
XP_063126637.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207602.2 → NP_997485.2  type 2 lactosamine alpha-2,3-sialyltransferase

    See identical proteins and their annotated locations for NP_997485.2

    Status: PROVISIONAL

    Source sequence(s)
    BC092560
    UniProtKB/Swiss-Prot
    P61943
    UniProtKB/TrEMBL
    F7F9B2, Q569D2
    Related
    ENSRNOP00000002255.4, ENSRNOT00000002255.6
    Conserved Domains (1) summary
    pfam00777
    Location:62 → 330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    55530120..55590950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270565.1 → XP_063126635.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

    UniProtKB/TrEMBL
    F7F9B2, Q569D2

  2. XM_006248210.5 → XP_006248272.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006248272.1

    UniProtKB/Swiss-Prot
    P61943
    UniProtKB/TrEMBL
    F7F9B2, Q569D2
    Conserved Domains (1) summary
    pfam00777
    Location:62 → 330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_063270567.1 → XP_063126637.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

  4. XM_006248209.5 → XP_006248271.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006248271.1

    UniProtKB/Swiss-Prot
    P61943
    UniProtKB/TrEMBL
    F7F9B2, Q569D2
    Conserved Domains (1) summary
    pfam00777
    Location:62 → 330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_039088389.2 → XP_038944317.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

  6. XM_039088388.2 → XP_038944316.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:62 → 197
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_039088387.2 → XP_038944315.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P61943
    UniProtKB/TrEMBL
    F7F9B2, Q569D2
    Conserved Domains (1) summary
    pfam00777
    Location:62 → 330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  8. XM_039088384.2 → XP_038944312.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P61943
    UniProtKB/TrEMBL
    F7F9B2, Q569D2
    Conserved Domains (1) summary
    pfam00777
    Location:62 → 330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  9. XM_039088386.2 → XP_038944314.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P61943
    UniProtKB/TrEMBL
    F7F9B2, Q569D2
    Conserved Domains (1) summary
    pfam00777
    Location:62 → 330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  10. XM_063270566.1 → XP_063126636.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61943.1 GenPept UniProtKB/Swiss-Prot:P61943

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