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Rbmx RNA binding motif protein, X-linked [ Rattus norvegicus (Norway rat) ]

Gene ID: 302855, updated on 18-Sep-2024

Summary

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Official Symbol
Rbmxprovided by RGD
Official Full Name
RNA binding motif protein, X-linkedprovided by RGD
Primary source
RGD:1565256
See related
EnsemblRapid:ENSRNOG00000000866 AllianceGenome:RGD:1565256
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
hnRNP G; hnRNP-G
Summary
Enables single-stranded RNA binding activity. Involved in mRNA splice site selection and positive regulation of transcription, DNA-templated. Located in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Shashi type. Orthologous to human RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 268.1), Kidney (RPKM 150.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (140342544..140352121, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (135305237..135314806, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (159881835..159891405, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene CD40 ligand Neighboring gene Rac/Cdc42 guanine nucleotide exchange factor 6 Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene transmembrane 9 superfamily member 2, pseudogene 1 Neighboring gene G protein-coupled receptor 101

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of RBMX in the light-induced damage of rat retina in vivo. Dai M, et al. Cell Mol Neurobiol, 2015 May. PMID 25407628
  2. Expression of RBMX after spinal cord injury in rats. Zhang J, et al. J Mol Neurosci, 2013 Feb. PMID 23180094
  3. Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. Kanhoush R, et al. Nucleus, 2010 Jan-Feb. PMID 21327109, Free PMC Article
  4. RNA binding proteins accumulate at the postsynaptic density with synaptic activity. Zhang G, et al. J Neurosci, 2012 Jan 11. PMID 22238095, Free PMC Article
  5. hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. Shin KH, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18541147, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RBMX might play a significant role in the degenerative process of retinal ganglion cells after light-induced damage in the retina.
    Title: Expression of RBMX in the light-induced damage of rat retina in vivo.
  2. RBMX immunoreactivity was found in neurons and astrocytes, but not in microglia after spinal cord injury.
    Title: Expression of RBMX after spinal cord injury in rats.
  3. hnRNP G is a nuclear protein that is expressed in different concentrations in various tissues and interacts with other splicing regulatory proteins.
    Title: Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC114544

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of supraspliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding motif protein, X chromosome
Names
RNA binding motif protein, X chromosome
RNA-binding motif protein, X chromosome retrogene
heterogeneous nuclear ribonucleoprotein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025663.1 → NP_001020834.1  RNA-binding motif protein, X chromosome

    See identical proteins and their annotated locations for NP_001020834.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097479
    UniProtKB/Swiss-Prot
    Q4V898
    UniProtKB/TrEMBL
    A0A8I6AKQ4
    Related
    ENSRNOP00000001154.6, ENSRNOT00000001154.9
    Conserved Domains (3) summary
    PRK14086
    Location:165 → 302
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    140342544..140352121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257680.5 → XP_006257742.1  RNA-binding motif protein, X chromosome isoform X1

    See identical proteins and their annotated locations for XP_006257742.1

    UniProtKB/Swiss-Prot
    Q4V898
    UniProtKB/TrEMBL
    A0A8I6AKQ4
    Conserved Domains (3) summary
    PRK14086
    Location:165 → 302
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

  2. XM_017602020.3 → XP_017457509.2  RNA-binding motif protein, X chromosome isoform X2

    UniProtKB/TrEMBL
    A6KSR2
    Conserved Domains (3) summary
    PRK14086
    Location:165 → 272
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

  3. XM_063279967.1 → XP_063136037.1  RNA-binding motif protein, X chromosome isoform X3

    UniProtKB/TrEMBL
    A6KSQ9, A6KSR2

  4. XM_006257682.4 → XP_006257744.1  RNA-binding motif protein, X chromosome isoform X1

    See identical proteins and their annotated locations for XP_006257744.1

    UniProtKB/Swiss-Prot
    Q4V898
    UniProtKB/TrEMBL
    A0A8I6AKQ4
    Conserved Domains (3) summary
    PRK14086
    Location:165 → 302
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

  5. XM_063279966.1 → XP_063136036.1  RNA-binding motif protein, X chromosome isoform X2

    UniProtKB/TrEMBL
    A6KSR2

  6. XM_017602021.3 → XP_017457510.1  RNA-binding motif protein, X chromosome isoform X3

    UniProtKB/TrEMBL
    A6KSQ9, A6KSR2
    Conserved Domains (3) summary
    COG0724
    Location:1 → 85
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family

  7. XM_006257683.5 → XP_006257745.1  RNA-binding motif protein, X chromosome isoform X1

    See identical proteins and their annotated locations for XP_006257745.1

    UniProtKB/Swiss-Prot
    Q4V898
    UniProtKB/TrEMBL
    A0A8I6AKQ4
    Conserved Domains (3) summary
    PRK14086
    Location:165 → 302
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V898.1 GenPept UniProtKB/Swiss-Prot:Q4V898

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