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Rbmx RNA binding motif protein, X chromosome [ Mus musculus (house mouse) ]

Gene ID: 19655, updated on 8-Nov-2022

Summary

Official Symbol
Rbmxprovided by MGI
Official Full Name
RNA binding motif protein, X chromosomeprovided by MGI
Primary source
MGI:MGI:1343044
See related
Ensembl:ENSMUSG00000031134 AllianceGenome:MGI:1343044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hnRNP G
Summary
Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to interleukin-1; and regulation of RNA metabolic process. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in euchromatin; extracellular exosome; and nucleus. Predicted to be part of catalytic step 2 spliceosome and supraspliceosomal complex. Is expressed in several structures, including central nervous system; female reproductive system; gut; sensory organ; and thymus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Shashi type. Orthologous to human RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 55.1), CNS E11.5 (RPKM 51.1) and 20 other tissues See more
Orthologs
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Genomic context

See Rbmx in Genome Data Viewer
Location:
X; X A6
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56428708..56438405, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57383348..57393046, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CD40 ligand Neighboring gene Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene transmembrane 9 superfamily member 5 Neighboring gene G protein-coupled receptor 101

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of supraspliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RNA-binding motif protein, X chromosome
Names
heterogeneous nuclear ribonucleoprotein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166623.1NP_001160095.1  RNA-binding motif protein, X chromosome

    See identical proteins and their annotated locations for NP_001160095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' UTR versus variant 1. Variants 1 and 3 encode the same functional protein.
    Source sequence(s)
    AK083899, AK135164
    Consensus CDS
    CCDS30153.1
    UniProtKB/Swiss-Prot
    Q9R0Y0, Q9WV02
    UniProtKB/TrEMBL
    A0A6P7QUL7, A0A8C6ICG3
    Related
    ENSMUSP00000110374.2, ENSMUST00000114726.8
    Conserved Domains (3) summary
    PRK14086
    Location:167306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
  2. NM_011252.4NP_035382.1  RNA-binding motif protein, X chromosome

    See identical proteins and their annotated locations for NP_035382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript. Variants 1 and 3 encode the same functional protein.
    Source sequence(s)
    AK083899, AK178027, BY279114, CK619886
    Consensus CDS
    CCDS30153.1
    UniProtKB/Swiss-Prot
    Q9R0Y0, Q9WV02
    UniProtKB/TrEMBL
    A0A6P7QUL7, A0A8C6ICG3
    Related
    ENSMUSP00000110378.2, ENSMUST00000114730.8
    Conserved Domains (3) summary
    PRK14086
    Location:167306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

RNA

  1. NR_029425.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate 3' sequence, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, probably not making a protein.
    Source sequence(s)
    AK004162, AK008618, AK165006, BY279114

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    56428708..56438405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161866.1XP_036017759.1  RNA-binding motif protein, X chromosome isoform X2

    UniProtKB/TrEMBL
    A0A6P7QM11
    Related
    ENSMUSP00000125720.2, ENSMUST00000140384.8
    Conserved Domains (2) summary
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
  2. XM_036161864.1XP_036017757.1  RNA-binding motif protein, X chromosome isoform X1

    UniProtKB/Swiss-Prot
    Q9R0Y0
    UniProtKB/TrEMBL
    A0A6P7QUL7, A0A8C6ICG3
    Conserved Domains (3) summary
    PRK14086
    Location:167306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
  3. XM_036161865.1XP_036017758.1  RNA-binding motif protein, X chromosome isoform X1

    UniProtKB/Swiss-Prot
    Q9R0Y0
    UniProtKB/TrEMBL
    A0A6P7QUL7, A0A8C6ICG3
    Conserved Domains (3) summary
    PRK14086
    Location:167306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins