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Cyc1 cytochrome c-1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300047, updated on 6-Jun-2024

Summary

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Official Symbol
Cyc1provided by RGD
Official Full Name
cytochrome c-1provided by RGD
Primary source
RGD:1306597
See related
Ensembl:ENSRNOG00000012457 AllianceGenome:RGD:1306597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable electron transfer activity; heme binding activity; and metal ion binding activity. Involved in response to glucagon. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2643.1), Muscle (RPKM 1732.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyc1 in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109947750..109950142)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108067106..108069483)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117409576..117411953)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 5-oxoprolinase (ATP-hydrolysing) Neighboring gene exosome component 4 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene SHANK-associated RH domain interactor Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stimulation of the respiratory chain of rat liver mitochondria between cytochrome c1 and cytochrome c by glucagon treatment of rats. Halestrap AP. Biochem J, 1978 Jun 15. PMID 210759, Free PMC Article
  2. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. Kuang E, et al. PLoS Genet, 2012. PMID 23093945, Free PMC Article
  3. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695
  4. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
  5. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to glucagon IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome c-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277194.1 → NP_001264123.1  cytochrome c-1

    See identical proteins and their annotated locations for NP_001264123.1

    Status: VALIDATED

    Source sequence(s)
    FM122421, FN801980, JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HS83, D3ZFQ8
    Related
    ENSRNOP00000017067.7, ENSRNOT00000017067.8
    Conserved Domains (2) summary
    COG2857
    Location:85 → 288
    CYT1; Cytochrome c1 [Energy production and conversion]
    pfam02167
    Location:97 → 315
    Cytochrom_C1; Cytochrome C1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109947750..109950142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263310.1 → XP_063119380.1  cytochrome c-1 isoform X1

    UniProtKB/TrEMBL
    D3ZFQ8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001130491.1: Suppressed sequence

    Description
    NM_001130491.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials