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CYC1 cytochrome c1 [ Homo sapiens (human) ]

Gene ID: 1537, updated on 19-Sep-2024

Summary

Official Symbol
CYC1provided by HGNC
Official Full Name
cytochrome c1provided by HGNC
Primary source
HGNC:HGNC:2579
See related
Ensembl:ENSG00000179091 MIM:123980; AllianceGenome:HGNC:2579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UQCR4; MC3DN6
Summary
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in heart (RPKM 77.6), duodenum (RPKM 50.4) and 25 other tissues See more
Orthologs
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Genomic context

See CYC1 in Genome Data Viewer
Location:
8q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144095076..144097525)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145255893..145258315)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145149979..145152428)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene exosome component 4 Neighboring gene uncharacterized LOC124902038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19654 Neighboring gene microRNA 6847 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145144930-145145430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145145431-145145931 Neighboring gene Sharpr-MPRA regulatory region 12380 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145150053-145150248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28088 Neighboring gene SHANK associated RH domain interactor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28089 Neighboring gene Sharpr-MPRA regulatory region 2030 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of cytochrome c-1 (CYC1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquinol-cytochrome-c reductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
Non-traceable Author Statement
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucagon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome c1, heme protein, mitochondrial
Names
complex III subunit 4
complex III subunit IV
cytochrome b-c1 complex subunit 4
cytochrome c-1
ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
NP_001907.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033872.2 RefSeqGene

    Range
    5002..7451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001916.5NP_001907.3  cytochrome c1, heme protein, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC104592
    Consensus CDS
    CCDS6415.1
    UniProtKB/Swiss-Prot
    P08574, Q5U062, Q6FHS7
    UniProtKB/TrEMBL
    Q8TBT6
    Related
    ENSP00000317159.4, ENST00000318911.5
    Conserved Domains (1) summary
    pfam02167
    Location:96314
    Cytochrom_C1; Cytochrome C1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144095076..144097525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145255893..145258315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)