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Nup133 nucleoporin 133 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292085, updated on 13-Apr-2024

Summary

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Official Symbol
Nup133provided by RGD
Official Full Name
nucleoporin 133provided by RGD
Primary source
RGD:1307827
See related
Ensembl:ENSRNOG00000017919 AllianceGenome:RGD:1307827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore organization; nucleocytoplasmic transport; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to act upstream of or within nervous system development; paraxial mesoderm development; and somite development. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 104.6), Spleen (RPKM 83.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nup133 in Genome Data Viewer
Location:
19q12
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68789065..68838692, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51891606..51941243, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56681965..56731404, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348965 Neighboring gene U6 spliceosomal RNA Neighboring gene actin, alpha 1, skeletal muscle Neighboring gene uncharacterized LOC134483405 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene ATP binding cassette subfamily B member 10 Neighboring gene TATA-box binding protein associated factor 5 like 1 Neighboring gene URB2 ribosome biogenesis homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex. Schrader N, et al. Structure, 2008 Jul. PMID 18611384
  2. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. Vasu S, et al. J Cell Biol, 2001 Oct 29. PMID 11684705, Free PMC Article
  3. Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. Braun DA, et al. J Clin Invest, 2018 Oct 1. PMID 30179222, Free PMC Article
  4. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A, et al. Genes (Basel), 2014 Sep 2. PMID 25184662, Free PMC Article
  5. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. Belgareh N, et al. J Cell Biol, 2001 Sep 17. PMID 11564755, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in nephron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear pore organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paraxial mesoderm development ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somite development ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore outer ring ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400955.1 → NP_001387884.1  nuclear pore complex protein Nup133

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    D3Z8B2
    Related
    ENSRNOP00000024182.6, ENSRNOT00000024182.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    68789065..68838692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772671.4 → XP_008770893.1  nuclear pore complex protein Nup133 isoform X1

    See identical proteins and their annotated locations for XP_008770893.1

    UniProtKB/TrEMBL
    A0A8I6A7P7
    Conserved Domains (1) summary
    pfam03177
    Location:469 → 954
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

  2. XM_039098297.2 → XP_038954225.1  nuclear pore complex protein Nup133 isoform X2

    Conserved Domains (1) summary
    pfam03177
    Location:61 → 460
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
Nucleotide Protein Strain
Heading Accession and Version

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