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UPK1B uroplakin 1B [ Bos taurus (cattle) ]

Gene ID: 282113, updated on 6-Jun-2024

Summary

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Official Symbol
UPK1Bprovided by VGNC
Official Full Name
uroplakin 1Bprovided by VGNC
Primary source
VGNC:VGNC:36685
See related
BGD:BT22372; Ensembl:ENSBTAG00000009014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See UPK1B in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (63981602..64010646)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101901963 Neighboring gene testis expressed 55 Neighboring gene beta-1,4-galactosyltransferase 4 Neighboring gene Rho GTPase activating protein 31

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. Yu J, et al. J Cell Biol, 1994 Apr. PMID 8138569, Free PMC Article
  2. Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition. Liang FX, et al. Biochem J, 2001 Apr 1. PMID 11256943, Free PMC Article
  3. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. Deng FM, et al. J Cell Biol, 2002 Nov 25. PMID 12446744, Free PMC Article
  4. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. Wu XR, et al. J Biol Chem, 1995 Dec 15. PMID 8530366
  5. Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. Tu L, et al. Mol Biol Cell, 2002 Dec. PMID 12475947, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC139202

Gene Ontology Provided by RefSeq

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
uroplakin-1b
Names
UP1b
UPIb
uroplakin IB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174482.2 → NP_776907.2  uroplakin-1b

    See identical proteins and their annotated locations for NP_776907.2

    Status: PROVISIONAL

    Source sequence(s)
    BC116014
    UniProtKB/Swiss-Prot
    P38573, Q1LZG4
    UniProtKB/TrEMBL
    A0AAA9SRM8
    Related
    ENSBTAP00000011866.6, ENSBTAT00000011866.6
    Conserved Domains (2) summary
    cd03156
    Location:118 → 230
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 258
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    63981602..64010646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005201259.5 → XP_005201316.2  uroplakin-1b isoform X1

    UniProtKB/TrEMBL
    A0AAA9SRM8, A0AAA9T558
    Related
    ENSBTAP00000093915.1, ENSBTAT00000123536.1
    Conserved Domains (1) summary
    cd03156
    Location:168 → 280
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. XM_010801071.4 → XP_010799373.2  uroplakin-1b isoform X2

    UniProtKB/TrEMBL
    A0AAA9SRM8
    Conserved Domains (1) summary
    cd03156
    Location:118 → 230
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  3. XM_005201261.5 → XP_005201318.2  uroplakin-1b isoform X2

    UniProtKB/TrEMBL
    A0AAA9SRM8
    Conserved Domains (1) summary
    cd03156
    Location:118 → 230
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  4. XM_024992546.1 → XP_024848314.1  uroplakin-1b isoform X3

    UniProtKB/TrEMBL
    A0AAA9SRM8
    Conserved Domains (1) summary
    cd03156
    Location:95 → 207
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38573.4 GenPept UniProtKB/Swiss-Prot:P38573

Gene LinkOut

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Molecular Biology Databases
Research Materials