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Upk1b uroplakin 1B [ Mus musculus (house mouse) ]

Gene ID: 22268, updated on 8-Dec-2022

Summary

Official Symbol
Upk1bprovided by MGI
Official Full Name
uroplakin 1Bprovided by MGI
Primary source
MGI:MGI:98912
See related
Ensembl:ENSMUSG00000049436 AllianceGenome:MGI:98912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UPIb; Upk1; Tspan20
Summary
Acts upstream of or within response to bacterium. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in genitourinary system; mesothelium; pharyngo-tympanic tube; pharynx epithelium; and skin. Orthologous to human UPK1B (uroplakin 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 393.9) and lung adult (RPKM 17.4) See more
Orthologs
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Genomic context

See Upk1b in Genome Data Viewer
Location:
16; 16 B4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38593544..38620565, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38773182..38800203, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 31 Neighboring gene anaphase promoting complex subunit 10 pseudogene Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 Neighboring gene RNA binding motif protein 39 pseudogene Neighboring gene testis expressed 55 Neighboring gene predicted gene 15802

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (3) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in apical plasma membrane urothelial plaque IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uroplakin-1b
Names
UP1b
uroplakin Ib

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178924.4NP_849255.2  uroplakin-1b

    See identical proteins and their annotated locations for NP_849255.2

    Status: VALIDATED

    Source sequence(s)
    AK053004, AK083101, AK086926, BB427704, D18653
    Consensus CDS
    CCDS28174.1
    UniProtKB/Swiss-Prot
    Q8K4M0, Q9Z2C6
    UniProtKB/TrEMBL
    A0A8C6HKR9
    Related
    ENSMUSP00000052469.5, ENSMUST00000057767.6
    Conserved Domains (1) summary
    cd03156
    Location:120230
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38593544..38620565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316943.2XP_017172432.1  uroplakin-1b isoform X1

    UniProtKB/Swiss-Prot
    Q8K4M0, Q9Z2C6
    UniProtKB/TrEMBL
    A0A8C6HKR9
    Conserved Domains (1) summary
    cd03156
    Location:120230
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...