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UPK1B uroplakin 1B [ Homo sapiens (human) ]

Gene ID: 7348, updated on 21-Dec-2018

Summary

Official Symbol
UPK1Bprovided by HGNC
Official Full Name
uroplakin 1Bprovided by HGNC
Primary source
HGNC:HGNC:12578
See related
Ensembl:ENSG00000114638 MIM:602380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UPIB; UPK1; TSPAN20
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in urinary bladder (RPKM 15.8), stomach (RPKM 12.4) and 5 other tissues See more
Orthologs

Genomic context

See UPK1B in Genome Data Viewer
Location:
3q13.32
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (119173578..119205153)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (118892425..118924000)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 11 Neighboring gene IGSF11 antisense RNA 1 Neighboring gene testis expressed 55 Neighboring gene B4GALT4 antisense RNA 1 Neighboring gene beta-1,4-galactosyltransferase 4 Neighboring gene Rho GTPase activating protein 31 Neighboring gene ribosomal protein S26 pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TEX55

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane urothelial plaque IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
uroplakin-1b
Names
UP1b
tetraspan
tetraspanin-20
tspan-20
uroplakin Ib

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006952.4NP_008883.2  uroplakin-1b

    See identical proteins and their annotated locations for NP_008883.2

    Status: REVIEWED

    Source sequence(s)
    AB002155, AL709739
    Consensus CDS
    CCDS2985.1
    UniProtKB/Swiss-Prot
    O75841
    Related
    ENSP00000264234.3, ENST00000264234.7
    Conserved Domains (2) summary
    cd03156
    Location:118230
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10258
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    119173578..119205153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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