Tst thiosulfate sulfurtransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tstprovided by RGD
Official Full Name: thiosulfate sulfurtransferaseprovided by RGD
Primary source: RGD:3913
See related: AllianceGenome:RGD:3913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RHODAN
Summary: Predicted to enable 5S rRNA binding activity and thiosulfate sulfurtransferase activity. Predicted to be involved in epithelial cell differentiation; rRNA import into mitochondrion; and transsulfuration. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human TST (thiosulfate sulfurtransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1887.6), Kidney (RPKM 1352.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111828557..111836980, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (109948061..109955378, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119616323..119623072, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-mercaptopyruvate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5S rRNA binding	IEA Inferred from Electronic Annotation more info
enables 5S rRNA binding	ISO Inferred from Sequence Orthology more info
enables 5S rRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sulfurtransferase activity	TAS Traceable Author Statement more info
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate sulfurtransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in rRNA import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in rRNA import into mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in rRNA import into mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA transport	ISO Inferred from Sequence Orthology more info
involved_in rRNA transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thiosulfate sulfurtransferase

Names: Thiosulfate sulphurtransferase (rhodanese); rhodanese; thiosulfate sulfurtransferase, mitochondrial

NP_036940.1

EC 2.8.1.1

XP_063119082.1

EC 2.8.1.1

XP_063119083.1

EC 2.8.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012808.1 → NP_036940.1 thiosulfate sulfurtransferase

See identical proteins and their annotated locations for NP_036940.1

Status: PROVISIONAL

Source sequence(s)

BC088449

UniProtKB/Swiss-Prot

P24329, Q5I0D4

UniProtKB/TrEMBL

A6HSJ7

Conserved Domains (1) summary

COG2897
Location:10 → 279

SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111828557..111836980 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263012.1 → XP_063119082.1 thiosulfate sulfurtransferase isoform X1

UniProtKB/TrEMBL

A0A8L2QJT5
XM_063263013.1 → XP_063119083.1 thiosulfate sulfurtransferase isoform X2

UniProtKB/Swiss-Prot

P24329, Q5I0D4

UniProtKB/TrEMBL

A6HSJ7