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Tst thiosulfate sulfurtransferase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 22117, updated on 31-Jan-2019

Summary

Official Symbol
Tstprovided by MGI
Official Full Name
thiosulfate sulfurtransferase, mitochondrialprovided by MGI
Primary source
MGI:MGI:98852
See related
Ensembl:ENSMUSG00000044986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rhodanese
Expression
Broad expression in liver adult (RPKM 153.9), adrenal adult (RPKM 109.2) and 17 other tissues See more
Orthologs

Genomic context

See Tst in Genome Data Viewer
Location:
15 E1; 15 37.47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (78399556..78405859, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (78229986..78236289, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Neighboring gene microRNA 7676-2 Neighboring gene testis expressed 33 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene predicted gene, 41355 Neighboring gene predicted gene, 36644

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

  • Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
    Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Cysteine and methionine metabolism, conserved biosystem (from KEGG)
    Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Sulfur metabolism, organism-specific biosystem (from KEGG)
    Sulfur metabolism, organism-specific biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Sulfur metabolism, conserved biosystem (from KEGG)
    Sulfur metabolism, conserved biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Sulfur relay system, organism-specific biosystem (from KEGG)
    Sulfur relay system, organism-specific biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
  • Sulfur relay system, conserved biosystem (from KEGG)
    Sulfur relay system, conserved biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
  • thiosulfate disproportionation III (rhodanese), organism-specific biosystem (from BIOCYC)
    thiosulfate disproportionation III (rhodanese), organism-specific biosystem
    thiosulfate disproportionation III (rhodanese)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
5S rRNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
thiosulfate sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
rRNA import into mitochondrion ISO
Inferred from Sequence Orthology
more info
 
rRNA transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane HDA PubMed 
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thiosulfate sulfurtransferase
NP_033463.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009437.5NP_033463.1  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_033463.1

    Status: VALIDATED

    Source sequence(s)
    AL583893
    Consensus CDS
    CCDS27614.1
    UniProtKB/Swiss-Prot
    P52196
    UniProtKB/TrEMBL
    Q545S0
    Related
    ENSMUSP00000055743.7, ENSMUST00000058659.8
    Conserved Domains (3) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    cd01445
    Location:11136
    TST_Repeats; Thiosulfate sulfurtransferases (TST) contain 2 copies of the Rhodanese Homology Domain. Only the second repeat contains the catalytically active Cys residue. The role of the 1st repeat is uncertain, but believed to be involved in protein interaction. ...
    cd01449
    Location:163281
    TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    78399556..78405859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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