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Tst thiosulfate sulfurtransferase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 22117, updated on 1-Mar-2024

Summary

Official Symbol
Tstprovided by MGI
Official Full Name
thiosulfate sulfurtransferase, mitochondrialprovided by MGI
Primary source
MGI:MGI:98852
See related
Ensembl:ENSMUSG00000044986 AllianceGenome:MGI:98852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rhodanese
Summary
Predicted to enable 5S rRNA binding activity and thiosulfate sulfurtransferase activity. Predicted to be involved in epithelial cell differentiation; rRNA import into mitochondrion; and transsulfuration. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TST (thiosulfate sulfurtransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 153.9), adrenal adult (RPKM 109.2) and 17 other tissues See more
Orthologs
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Genomic context

See Tst in Genome Data Viewer
Location:
15 E1; 15 37.47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78283756..78290065, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78399556..78405865, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Neighboring gene microRNA 7676-2 Neighboring gene ciliary microtubule inner protein 4 Neighboring gene STARR-seq mESC enhancer starr_39143 Neighboring gene predicted gene, 52185 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene predicted gene, 36644 Neighboring gene predicted gene, 41355

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-mercaptopyruvate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 5S rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thiosulfate sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA import into mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thiosulfate sulfurtransferase
NP_033463.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009437.5NP_033463.1  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_033463.1

    Status: VALIDATED

    Source sequence(s)
    AL583893
    Consensus CDS
    CCDS27614.1
    UniProtKB/Swiss-Prot
    P52196
    UniProtKB/TrEMBL
    Q545S0
    Related
    ENSMUSP00000055743.8, ENSMUST00000058659.9
    Conserved Domains (3) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
    cd01445
    Location:11136
    TST_Repeats; Thiosulfate sulfurtransferases (TST) contain 2 copies of the Rhodanese Homology Domain. Only the second repeat contains the catalytically active Cys residue. The role of the 1st repeat is uncertain, but believed to be involved in protein interaction. ...
    cd01449
    Location:163281
    TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78283756..78290065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)