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TST thiosulfate sulfurtransferase [ Homo sapiens (human) ]

Gene ID: 7263, updated on 1-Jun-2020

Summary

Official Symbol
TSTprovided by HGNC
Official Full Name
thiosulfate sulfurtransferaseprovided by HGNC
Primary source
HGNC:HGNC:12388
See related
Ensembl:ENSG00000128311 MIM:180370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDS
Summary
This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues See more
Orthologs

Genomic context

See TST in Genome Data Viewer
Location:
22q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (37010859..37020183, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37406900..37416224, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr22.1657 Neighboring gene testis expressed 33 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene uncharacterized LOC112268295 Neighboring gene RN7SK pseudogene 214 Neighboring gene potassium channel tetramerization domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5S rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiosulfate sulfurtransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cyanate catabolic process TAS
Traceable Author Statement
more info
PubMed 
epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
rRNA import into mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA transport IDA
Inferred from Direct Assay
more info
PubMed 
sulfur amino acid catabolic process TAS
Traceable Author Statement
more info
 
transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
thiosulfate sulfurtransferase
Names
epididymis secretory sperm binding protein
thiosulfate sulfurtransferase (rhodanese)
NP_001257412.1
NP_003303.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027994.1 RefSeqGene

    Range
    5004..13586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270483.1NP_001257412.1  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_001257412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW070418, BQ231617, Z73420
    Consensus CDS
    CCDS13938.1
    UniProtKB/Swiss-Prot
    Q16762
    Related
    ENSP00000478739.1, ENST00000622841.1
    Conserved Domains (1) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
  2. NM_003312.6NP_003303.2  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_003303.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI869664, BC010148
    Consensus CDS
    CCDS13938.1
    UniProtKB/Swiss-Prot
    Q16762
    Related
    ENSP00000249042.3, ENST00000249042.8
    Conserved Domains (1) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    37010859..37020183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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