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TST thiosulfate sulfurtransferase [ Homo sapiens (human) ]

Gene ID: 7263, updated on 7-Dec-2018

Summary

Official Symbol
TSTprovided by HGNC
Official Full Name
thiosulfate sulfurtransferaseprovided by HGNC
Primary source
HGNC:HGNC:12388
See related
Ensembl:ENSG00000128311 MIM:180370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDS
Summary
This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues See more
Orthologs

Genomic context

See TST in Genome Data Viewer
Location:
22q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (37010859..37020183, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37406900..37416224, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein FLJ39582-like Neighboring gene testis expressed 33 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene uncharacterized LOC112268295 Neighboring gene RNA, 7SK small nuclear pseudogene 214 Neighboring gene potassium channel tetramerization domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
    Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Cysteine and methionine metabolism, conserved biosystem (from KEGG)
    Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Degradation of cysteine and homocysteine, organism-specific biosystem (from REACTOME)
    Degradation of cysteine and homocysteine, organism-specific biosystemWhile in humans excess methionine is converted to homocysteine, homocysteine and its transsulfuration product cysteine can be degraded to several end products, two of which, taurine and hydrogen sulf...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Sulfide oxidation to sulfate, organism-specific biosystem (from REACTOME)
    Sulfide oxidation to sulfate, organism-specific biosystemWhile the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is...
  • Sulfur amino acid metabolism, organism-specific biosystem (from REACTOME)
    Sulfur amino acid metabolism, organism-specific biosystemThe main sulfur amino acids are methionine, cysteine, homocysteine and taurine. Of these, the first two are proteinogenic.This group of reactions contains all processes that 1) break down sulfur amin...
  • Sulfur metabolism, organism-specific biosystem (from KEGG)
    Sulfur metabolism, organism-specific biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Sulfur metabolism, conserved biosystem (from KEGG)
    Sulfur metabolism, conserved biosystemSulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in...
  • Sulfur relay system, organism-specific biosystem (from KEGG)
    Sulfur relay system, organism-specific biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
  • Sulfur relay system, conserved biosystem (from KEGG)
    Sulfur relay system, conserved biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5S rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
thiosulfate sulfurtransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cyanate catabolic process TAS
Traceable Author Statement
more info
PubMed 
epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
rRNA import into mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA transport IDA
Inferred from Direct Assay
more info
PubMed 
sulfur amino acid catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular space HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
thiosulfate sulfurtransferase
Names
epididymis secretory sperm binding protein
thiosulfate sulfurtransferase (rhodanese)
NP_001257412.1
NP_003303.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027994.1 RefSeqGene

    Range
    4998..13592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270483.1NP_001257412.1  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_001257412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW070418, BQ231617, Z73420
    Consensus CDS
    CCDS13938.1
    UniProtKB/Swiss-Prot
    Q16762
    Related
    ENSP00000478739.1, ENST00000622841.1
    Conserved Domains (1) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
  2. NM_003312.6NP_003303.2  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_003303.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI869664, BC010148
    Consensus CDS
    CCDS13938.1
    UniProtKB/Swiss-Prot
    Q16762
    Related
    ENSP00000249042.3, ENST00000249042.7
    Conserved Domains (1) summary
    COG2897
    Location:10279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    37010859..37020183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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