Faim2 Fas apoptotic inhibitory molecule 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Faim2provided by RGD
Full Name: Fas apoptotic inhibitory molecule 2provided by RGD
Primary source: RGD:628744
See related: EnsemblRapid:ENSRNOG00000045554 AllianceGenome:RGD:628744
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lfg; NMP35
Summary: Involved in central nervous system development. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane raft. Biomarker of chronic obstructive pulmonary disease. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 390.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132512095..132539192, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130632368..130659353, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141158769..141185781, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that NMP35 supports axonal growth, and overexpression of an axonally targeted NMP35 mRNA is sufficient to increase axonal outgrowth.
Title: Axonal transport of neural membrane protein 35 mRNA increases axon growth.
expression of Etv5, Faim2, Fto, Negr1 but not Sh2b1 is affected by nutritional state in these two areas, and the relationship between nutritional state and expression levels of obesity-associated genes in two brain areas relevant to feeding.
Title: Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1.
LFG mediated the FasL resistance of cerebellar granular cells to apoptosis
Title: FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35.
NMP35 protein occurs throughout the brain and spinal cord, especially in dendrites of several neuronal cell types and in the surrounding neuropil. NMP35 co-localizes with the glutamate receptor GluR2 and the presynaptic vesicle protein synaptophysin.
Title: Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135379 (e-PCR)
- UniSTS:218656

RH144326 (e-PCR)
- UniSTS:233571

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar Purkinje cell layer development	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell layer development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar granular layer development	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granular layer development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellum development	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein lifeguard 2

Names: lifeguard; neural membrane protein 35; protein lifeguard 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144756.2 → NP_653357.1 protein lifeguard 2

See identical proteins and their annotated locations for NP_653357.1

Status: PROVISIONAL

Source sequence(s)

BC087606

UniProtKB/Swiss-Prot

O88407

UniProtKB/TrEMBL

A6KCF9, M0R531

Related

ENSRNOP00000064487.3, ENSRNOT00000072309.4

Conserved Domains (1) summary

cd10428
Location:92 → 312

LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

132512095..132539192 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594665.3 → XP_017450154.1 protein lifeguard 2 isoform X1

UniProtKB/TrEMBL

M0R531

Conserved Domains (1) summary

cd10428
Location:80 → 300

LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis