Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Serpine1provided by RGD
Official Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1provided by RGD
Primary source: RGD:3249
See related: Ensembl:ENSRNOG00000001414
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Pai1; PAI1A; Planh; Pai1aa; RATPAI1A
Summary: mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator; may promote neuronal survival [RGD, Feb 2006]

Genomic context

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Location :: 12q11-q12

Sequence :: Chromosome: 12; NC_005111.3 (24653385..24663763)

See Serpine1 in MapViewer

Chromosome 12 - NC_005111.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

adhesion scores, PAI-1 activity in peritoneal lavage fluid, and PAI-1 mRNA levels in peritoneal mesothelium were significantly greater in the open surgery group than the control and laparoscopic surgery groups
Title: Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery.
This study supports that a preceding progesterone-enriched milieu prevented the enhanced prothrombotic risk induced by a fructose-rich diet-elicited high PAI-1 production.
Title: Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: protective effect of progesterone.
down-regulation of PAI-1 and MMP-9 might contribute to abnormal programming of renal growth in rats exposed to postnatal early overnutrition
Title: Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats.
The data demonstrate that PAI-1 siRNA inhibits alveolitis and pulmonary fibrosis in bleomycin-treated rats via inhibiting the proliferation and promoting the apoptosis of fibroblasts.
Title: siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats.
mRNA, protein and activity of matrix metalloproteinase (MMP)-2 and MMP-9 and mRNA of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were quantified in abdominal aorta (AA) and femoral artery (FA).
Title: Physiological regulation of MMPs and tPA/PAI in the arterial wall of rats by noradrenergic tone and angiotensin II.
Angiotensin II not only significantly induces PARP-1 expression and activity, but also increases PAI-1 and fibronectin expression in rat mesangial cells.
Title: Poly(ADP-ribose) polymerase-1 mediates angiotensin II-induced expression of plasminogen activator inhibitor-1 and fibronectin in rat mesangial cells.
Hydrocortisone up-regulates PAI-1 expression in a tissue-specific manner along with down-regulation of tPA activity in both normal and inflammatory conditions.
Title: Regulation of tissue plasminogen activator/plasminogen activator inhibitor-1 by hydrocortisone in rat primary astrocytes.
The activity of tissue plasminogen activator peaks transiently and then decreases in cortex and striatum along with delayed induction of PAI-1 in the inflammatory stage after reperfusion injury.
Title: Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: essential role of astrocyte-derived plasminogen activator inhibitor-1.
Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue stimulation.
Title: The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles.
PAI-1 derived from the neurovascular unit and peripheral vascular system participates as a positive regulator of the blood-brain barrier in facilitating the barrier function of the endothelial tight junctions.
Title: Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1.

Submit: New GeneRIF Correction See all (53)

Pathways from BioSystems

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Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem (from REACTOME)
BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...
Brain derived neurotrophic factor, organism-specific biosystem (from WikiPathways)
Brain derived neurotrophic factor, organism-specific biosystem
Brain derived neurotrophic factor
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Circadian Clock, organism-specific biosystem (from REACTOME)
Circadian Clock, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
Complement and Coagulation Cascades, organism-specific biosystem
Complement and Coagulation Cascades
Complement and coagulation cascades, organism-specific biosystem (from KEGG)
Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Complement and coagulation cascades, conserved biosystem (from KEGG)
Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
Dissolution of Fibrin Clot, organism-specific biosystemcomputationally inferred pathway (not manually curated)
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
p53 pathway, organism-specific biosystem (from WikiPathways)
p53 pathway, organism-specific biosystemp53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cyc...
p53 signaling pathway, organism-specific biosystem (from KEGG)
p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53 signaling pathway, conserved biosystem (from KEGG)
p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

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Markers

RH94577 (e-PCR)
- UniSTS:119825

D12Wox12 (e-PCR)
- UniSTS:118089

PMC15197P3 (e-PCR)
- UniSTS:271197

D12Wox11 (e-PCR)
- UniSTS:118111

D5Kyo2 (e-PCR), detects polymorphism
- UniSTS:118111

D12MIT2 (e-PCR)
- UniSTS:120159

RH142420 (e-PCR)
- UniSTS:231667

RH129692 (e-PCR)
- UniSTS:212988

Homology

Homologs of the Serpine1 gene: The Serpine1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, zebrafish, and mosquito.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
protease binding	IEA Inferred from Electronic Annotation more info
protease binding	ISO Inferred from Sequence Orthology more info
receptor binding	IEA Inferred from Electronic Annotation more info
contributes_to receptor binding	ISO Inferred from Sequence Orthology more info
serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
serine-type endopeptidase inhibitor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
angiogenesis	ISO Inferred from Sequence Orthology more info
cellular response to chemical stimulus	ISO Inferred from Sequence Orthology more info
cellular response to gravity	IEP Inferred from Expression Pattern more info	PubMed
cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
chronological cell aging	IEA Inferred from Electronic Annotation more info
chronological cell aging	ISO Inferred from Sequence Orthology more info
defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
glucose homeostasis	IEP Inferred from Expression Pattern more info	PubMed
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of endopeptidase activity	IC Inferred by Curator more info	PubMed
negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
negative regulation of fibrinolysis	IEA Inferred from Electronic Annotation more info
negative regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
negative regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
negative regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
negative regulation of proteolysis	TAS Traceable Author Statement more info	PubMed
negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of smooth muscle cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
negative regulation of vascular wound healing	IEA Inferred from Electronic Annotation more info
negative regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info
positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
positive regulation of coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
positive regulation of leukotriene production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
positive regulation of leukotriene production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
positive regulation of monocyte chemotaxis	IEA Inferred from Electronic Annotation more info
positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
positive regulation of receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
regulation of receptor activity	IEA Inferred from Electronic Annotation more info
regulation of receptor activity	ISO Inferred from Sequence Orthology more info
response to cytokine stimulus	IEP Inferred from Expression Pattern more info
response to estrogen stimulus	IEP Inferred from Expression Pattern more info
response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
response to reactive oxygen species	IEP Inferred from Expression Pattern more info	PubMed
tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
extracellular matrix	IEA Inferred from Electronic Annotation more info
extracellular matrix	ISO Inferred from Sequence Orthology more info
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular space	IDA Inferred from Direct Assay more info
extracellular space	IEA Inferred from Electronic Annotation more info
extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasminogen activator inhibitor 1

Names: plasminogen activator inhibitor 1; PAI; PAI-1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, member 1; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012620.1 → NP_036752.1 plasminogen activator inhibitor 1 precursor

Status: PROVISIONAL

Source sequence(s)

M24067

UniProtKB/Swiss-Prot

P20961

Related

ENSRNOP00000001916, ENSRNOT00000001916

Conserved Domains (2) summary

PHA02660
Location:54 – 402
Blast Score: 192

PHA02660; serpin-like protein; Provisional

cl00137
Location:26 – 402
Blast Score: 1321

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005111.3 Reference Rnor_5.0 Primary Assembly

Range

24653385..24663763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000080.1 Alternate Rn_Celera

Range

21377028..21387410

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AABR06071123.1 (1173..11551)	None
genomic	AAHX01071699.1 (4476..14858)	None
genomic	CH473973.1	EDM13286.1
genomic	J05206.1	AAA41796.1
mRNA	M24067.1	AAA56856.1	BUF