Format

Send to:

Choose Destination

Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 [ Mus musculus (house mouse) ]

Gene ID: 18787, updated on 3-Jun-2018
Official Symbol
Serpine1provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade E, member 1provided by MGI
Primary source
MGI:MGI:97608
See related
Ensembl:ENSMUSG00000037411 Vega:OTTMUSG00000054456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAI1; PAI-1; Planh1
Expression
Biased expression in placenta adult (RPKM 80.4), liver E18 (RPKM 11.4) and 3 other tissues See more
Orthologs
See Serpine1 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (137061504..137072272, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137537374..137548142, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene VGF nerve growth factor inducible Neighboring gene adaptor protein complex AP-1, sigma 1 Neighboring gene tripartite motif-containing 56 Neighboring gene mucin 3, intestinal Neighboring gene predicted gene, 40348

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
dentinogenesis ISO
Inferred from Sequence Orthology
more info
 
female gonad development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of plasminogen activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of coagulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukotriene production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
replicative senescence ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromaffin granule ISO
Inferred from Sequence Orthology
more info
 
collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
plasminogen activator inhibitor 1
Names
PAI
Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
endothelial plasminogen activator inhibitor
nexin, plasminogen activator inhibitor type 1
plasminogen activator inhibitor, type I
serine (or cysteine) proteinase inhibitor, clade E, member 1
serpin E1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008871.2NP_032897.2  plasminogen activator inhibitor 1 precursor

    See identical proteins and their annotated locations for NP_032897.2

    Status: VALIDATED

    Source sequence(s)
    AC147986
    Consensus CDS
    CCDS19761.1
    UniProtKB/TrEMBL
    G5E899
    Related
    ENSMUSP00000039586.4, OTTMUSP00000071541, ENSMUST00000041388.10, OTTMUST00000135048
    Conserved Domains (1) summary
    cl00137
    Location:29402
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    137061504..137072272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center