Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpine1provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade E, member 1provided by MGI
Primary source: MGI:MGI:97608
See related: Ensembl:ENSMUSG00000037411 AllianceGenome:MGI:97608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAI1; PAI-1; Planh1
Summary: Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Alzheimer's disease and Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in placenta adult (RPKM 80.4), liver E18 (RPKM 11.4) and 3 other tissues See more
Orthologs: all
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Genomic context

Location:: 5 G2; 5 76.16 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137090358..137101126, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137061504..137072272, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAI-1 deficiency drives pulmonary vascular smooth muscle remodeling and pulmonary hypertension.
Title: PAI-1 deficiency drives pulmonary vascular smooth muscle remodeling and pulmonary hypertension.
Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1.
Title: Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1.
Roles of Plasminogen Activator Inhibitor-1 in Heterotopic Ossification Induced by Achilles Tenotomy in Thermal Injured Mice.
Title: Roles of Plasminogen Activator Inhibitor-1 in Heterotopic Ossification Induced by Achilles Tenotomy in Thermal Injured Mice.
Cutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis.
Title: Cutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis.
Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice.
Title: Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice.
PAI-1 mediates TGF-beta1-induced myofibroblast activation in tenocytes via mTOR signaling.
Title: PAI-1 mediates TGF-β1-induced myofibroblast activation in tenocytes via mTOR signaling.
PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells.
Title: PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells.
PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by targeting CHRNA1.
Title: PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by targeting CHRNA1.
PAI-1 regulates AT2-mediated re-alveolarization and ion permeability.
Title: PAI-1 regulates AT2-mediated re-alveolarization and ion permeability.
SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption.
Title: SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption.

Submit: New GeneRIF Correction See all GeneRIFs (255)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M33960 (e-PCR)
- UniSTS:124952

Serpine1 (e-PCR), detects polymorphism
- UniSTS:144213

M33960 (e-PCR)
- UniSTS:179292

PMC15197P3 (e-PCR)
- UniSTS:271197

Serpine1 (e-PCR), detects polymorphism
- UniSTS:525943

NoName (e-PCR)
- UniSTS:548546

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in dentinogenesis	ISO Inferred from Sequence Orthology more info
involved_in female gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibrinolysis	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of plasminogen activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasminogen activation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vascular wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelium regeneration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukotriene production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromaffin granule	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of peptidase inhibitor complex	ISO Inferred from Sequence Orthology more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasminogen activator inhibitor 1

Names: PAI; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; plasminogen activator inhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E, member 1; serpin E1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008871.2 → NP_032897.2 plasminogen activator inhibitor 1 precursor

See identical proteins and their annotated locations for NP_032897.2

Status: VALIDATED

Source sequence(s)

AC147986

Consensus CDS

CCDS19761.1

UniProtKB/Swiss-Prot

P22777

UniProtKB/TrEMBL

G5E899

Related

ENSMUSP00000039586.5, ENSMUST00000041388.11

Conserved Domains (1) summary

cl00137
Location:29 → 402

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...