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Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 [ Mus musculus (house mouse) ]

Gene ID: 18787, updated on 27-Feb-2024

Summary

Official Symbol
Serpine1provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade E, member 1provided by MGI
Primary source
MGI:MGI:97608
See related
Ensembl:ENSMUSG00000037411 AllianceGenome:MGI:97608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAI1; PAI-1; Planh1
Summary
Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 80.4), liver E18 (RPKM 11.4) and 3 other tissues See more
Orthologs
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Genomic context

See Serpine1 in Genome Data Viewer
Location:
5 G2; 5 76.16 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137090358..137101126, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137061504..137072272, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14633 Neighboring gene STARR-positive B cell enhancer ABC_E10359 Neighboring gene VGF nerve growth factor inducible Neighboring gene STARR-positive B cell enhancer ABC_E4796 Neighboring gene adaptor protein complex AP-1, sigma 1 Neighboring gene STARR-seq mESC enhancer starr_14636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137579031-137579214 Neighboring gene tripartite motif-containing 56 Neighboring gene mucin 17, cell surface associated Neighboring gene predicted gene, 40348

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in dentinogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in female gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibrinolysis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of plasminogen activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of plasminogen activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular wound healing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelium regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukotriene production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in replicative senescence ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromaffin granule ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of peptidase inhibitor complex ISO
Inferred from Sequence Orthology
more info
 
part_of serine protease inhibitor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plasminogen activator inhibitor 1
Names
PAI
Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
endothelial plasminogen activator inhibitor
nexin, plasminogen activator inhibitor type 1
plasminogen activator inhibitor, type I
serine (or cysteine) proteinase inhibitor, clade E, member 1
serpin E1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008871.2NP_032897.2  plasminogen activator inhibitor 1 precursor

    See identical proteins and their annotated locations for NP_032897.2

    Status: VALIDATED

    Source sequence(s)
    AC147986
    Consensus CDS
    CCDS19761.1
    UniProtKB/Swiss-Prot
    P22777
    UniProtKB/TrEMBL
    G5E899
    Related
    ENSMUSP00000039586.5, ENSMUST00000041388.11
    Conserved Domains (1) summary
    cl00137
    Location:29402
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137090358..137101126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)