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ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 [ Neogale vison (American mink) ]

Gene ID: 122918282, updated on 22-Mar-2024

Summary

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Gene symbol
ARHGEF2
Gene description
Rho/Rac guanine nucleotide exchange factor 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Neogale vison
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Neogale
Also known as
Q5VY93
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
34
Annotation release Status Assembly Chr Location
100 current ASM_NN_V1 (GCF_020171115.1) 10 NC_058100.1 (1785397..1823376, complement)

Chromosome 10 - NC_058100.1Genomic Context describing neighboring genes Neighboring gene Ras like without CAAX 1 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene signal sequence receptor subunit 2 Neighboring gene ubiquilin 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_058100.1 Chromosome 10 Reference ASM_NN_V1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 2
Names
Rho/Rac guanine nucleotide exchange factor (GEF) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neovison vison Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM_NN_V1 Primary Assembly

Genomic

  1. NC_058100.1 Reference ASM_NN_V1 Primary Assembly

    Range
    1785397..1823376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044266539.1 → XP_044122474.1  rho guanine nucleotide exchange factor 2 isoform X4

    Conserved Domains (4) summary
    smart00109
    Location:240 → 286
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:437 → 631
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:934 → 1068
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:671 → 786
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  2. XM_044266538.1 → XP_044122473.1  rho guanine nucleotide exchange factor 2 isoform X3

    Conserved Domains (4) summary
    smart00109
    Location:240 → 286
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:435 → 629
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:909 → 1061
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:669 → 784
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  3. XM_044266536.1 → XP_044122471.1  rho guanine nucleotide exchange factor 2 isoform X1

    Conserved Domains (4) summary
    smart00109
    Location:240 → 286
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:435 → 629
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:932 → 1066
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:669 → 784
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  4. XM_044266537.1 → XP_044122472.1  rho guanine nucleotide exchange factor 2 isoform X2

    Conserved Domains (4) summary
    smart00109
    Location:240 → 286
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:437 → 631
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:911 → 1063
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:671 → 786
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  5. XM_044266540.1 → XP_044122475.1  rho guanine nucleotide exchange factor 2 isoform X5

    Conserved Domains (4) summary
    smart00109
    Location:240 → 286
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:437 → 631
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:934 → 1068
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:671 → 786
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  6. XM_044266542.1 → XP_044122477.1  rho guanine nucleotide exchange factor 2 isoform X6

    Conserved Domains (4) summary
    smart00109
    Location:78 → 124
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:275 → 469
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:749 → 901
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:509 → 624
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  7. XM_044266547.1 → XP_044122482.1  rho guanine nucleotide exchange factor 2 isoform X11

    Conserved Domains (5) summary
    smart00109
    Location:25 → 71
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:222 → 416
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:719 → 853
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02680
    Location:791 → 852
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:456 → 571
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  8. XM_044266551.1 → XP_044122486.1  rho guanine nucleotide exchange factor 2 isoform X13

    Conserved Domains (5) summary
    smart00109
    Location:13 → 59
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:210 → 404
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:707 → 841
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02680
    Location:779 → 840
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:444 → 559
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  9. XM_044266550.1 → XP_044122485.1  rho guanine nucleotide exchange factor 2 isoform X13

    Conserved Domains (5) summary
    smart00109
    Location:13 → 59
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:210 → 404
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:707 → 841
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02680
    Location:779 → 840
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:444 → 559
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  10. XM_044266545.1 → XP_044122480.1  rho guanine nucleotide exchange factor 2 isoform X9

    Conserved Domains (4) summary
    smart00109
    Location:40 → 86
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:235 → 429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:709 → 861
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:469 → 584
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  11. XM_044266548.1 → XP_044122483.1  rho guanine nucleotide exchange factor 2 isoform X12

    Conserved Domains (4) summary
    smart00109
    Location:40 → 86
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:237 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:711 → 863
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:471 → 586
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  12. XM_044266544.1 → XP_044122479.1  rho guanine nucleotide exchange factor 2 isoform X8

    Conserved Domains (4) summary
    smart00109
    Location:40 → 86
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:237 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:711 → 863
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13393
    Location:471 → 586
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  13. XM_044266543.1 → XP_044122478.1  rho guanine nucleotide exchange factor 2 isoform X7

    Conserved Domains (5) summary
    smart00109
    Location:40 → 86
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:237 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:734 → 868
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02680
    Location:806 → 867
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:471 → 586
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  14. XM_044266549.1 → XP_044122484.1  rho guanine nucleotide exchange factor 2 isoform X13

    Conserved Domains (5) summary
    smart00109
    Location:13 → 59
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:210 → 404
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:707 → 841
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02680
    Location:779 → 840
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:444 → 559
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  15. XM_044266552.1 → XP_044122487.1  rho guanine nucleotide exchange factor 2 isoform X13

    Conserved Domains (5) summary
    smart00109
    Location:13 → 59
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:210 → 404
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:707 → 841
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02680
    Location:779 → 840
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:444 → 559
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

  16. XM_044266546.1 → XP_044122481.1  rho guanine nucleotide exchange factor 2 isoform X10

    Conserved Domains (5) summary
    smart00109
    Location:32 → 78
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd00160
    Location:229 → 423
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:726 → 860
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02680
    Location:798 → 859
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:463 → 578
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
Nucleotide Protein
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