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Pou2f2 POU class 2 homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117058, updated on 17-Aug-2024

Summary

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Official Symbol
Pou2f2provided by RGD
Official Full Name
POU class 2 homeobox 2provided by RGD
Primary source
RGD:621690
See related
EnsemblRapid:ENSRNOG00000055650 AllianceGenome:RGD:621690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oct2; 2-Oct
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 33.0), Thymus (RPKM 6.8) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89810153..89897560, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80682330..80769756, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81966791..82049116, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene zinc finger protein 574 Neighboring gene uncharacterized LOC103691054 Neighboring gene U6 spliceosomal RNA Neighboring gene death effector domain containing 2 Neighboring gene zinc finger protein 526 Neighboring gene glycogen synthase kinase 3 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oct-2 transcription factor binding activity and expression up-regulation in rat cerebral ischaemia is associated with a diminution of neuronal damage in vitro. Camós S, et al. Neuromolecular Med, 2014 Jun. PMID 24282026
  2. Alcohol alters insulin-like growth factor-1 activated oct 2 POU domain gene expression in the immature female hypothalamus. Dees WL, et al. J Stud Alcohol, 2005 Jan. PMID 15830901
  3. Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2. Habu Y, et al. Biochem Pharmacol, 2003 Sep 15. PMID 12963498
  4. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Corcoran LM, et al. Genes Dev, 1993 Apr. PMID 8096198
  5. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. Scheidereit C, et al. Nature, 1988 Dec 8. PMID 2904654

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
    Title: CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
  2. Oct-2 expression and binding activity increase in the late phase of cerebral ischaemia. It is involved in reducing ischaemic-mediated neuronal injury.
    Title: Oct-2 transcription factor binding activity and expression up-regulation in rat cerebral ischaemia is associated with a diminution of neuronal damage in vitro.
  3. OCT2 efficiently translocates agmatine and must be considered for the control of agmatine levels.
    Title: Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).
  4. Oct 2 POU gene is a likely target by which alcohol can interfere with glial-neuronal interactions and interrupt LHRH secretion during prepubertal development.
    Title: Alcohol alters insulin-like growth factor-1 activated oct 2 POU domain gene expression in the immature female hypothalamus.
  5. It showed decreased basolateral organic anion and cation transport activity, accompanied by a specific decrease in rOAT1, rOAT3 and rOCT2 expression in hyperuricemic rat kidney.
    Title: Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables spermidine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mature B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
POU domain, class 2, transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271204.2 → NP_001258133.2  POU domain, class 2, transcription factor 2

    See identical proteins and their annotated locations for NP_001258133.2

    Status: VALIDATED

    Source sequence(s)
    FQ225995, L25863
    UniProtKB/TrEMBL
    A0A8I6A6L7
    Conserved Domains (2) summary
    smart00352
    Location:179 → 253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284 → 337
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    89810153..89897560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588679.3 → XP_017444168.1  POU domain, class 2, transcription factor 2 isoform X3

    Conserved Domains (3) summary
    smart00352
    Location:315 → 389
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:219 → 336
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:420 → 474
    Homeobox; Homeobox domain

  2. XM_039113041.2 → XP_038968969.1  POU domain, class 2, transcription factor 2 isoform X3

    Conserved Domains (3) summary
    smart00352
    Location:315 → 389
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:219 → 336
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:420 → 474
    Homeobox; Homeobox domain

  3. XM_039113091.2 → XP_038969019.1  POU domain, class 2, transcription factor 2 isoform X5

    Related
    ENSRNOP00000107534.1, ENSRNOT00000147093.1
    Conserved Domains (3) summary
    smart00352
    Location:305 → 379
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:209 → 326
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:410 → 464
    Homeobox; Homeobox domain

  4. XM_063266973.1 → XP_063123043.1  POU domain, class 2, transcription factor 2 isoform X10

  5. XM_039113129.2 → XP_038969057.1  POU domain, class 2, transcription factor 2 isoform X6

    Conserved Domains (2) summary
    smart00352
    Location:294 → 368
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:399 → 453
    Homeobox; Homeobox domain

  6. XM_039113067.2 → XP_038968995.1  POU domain, class 2, transcription factor 2 isoform X4

    Conserved Domains (3) summary
    smart00352
    Location:310 → 384
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:203 → 331
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:415 → 469
    Homeobox; Homeobox domain

  7. XM_017588683.3 → XP_017444172.1  POU domain, class 2, transcription factor 2 isoform X8

    Related
    ENSRNOP00000089154.2, ENSRNOT00000103845.2

  8. XM_039112962.2 → XP_038968890.1  POU domain, class 2, transcription factor 2 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:327 → 401
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:231 → 348
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:432 → 486
    Homeobox; Homeobox domain

  9. XM_017588686.3 → XP_017444175.1  POU domain, class 2, transcription factor 2 isoform X14

    UniProtKB/TrEMBL
    A0A8I6A150

  10. XM_017588685.3 → XP_017444174.1  POU domain, class 2, transcription factor 2 isoform X13

    UniProtKB/TrEMBL
    A0A8I6A150
    Related
    ENSRNOP00000084371.2, ENSRNOT00000104344.2

  11. XM_039113188.2 → XP_038969116.1  POU domain, class 2, transcription factor 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6A150
    Conserved Domains (2) summary
    smart00352
    Location:212 → 286
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:317 → 371
    Homeobox; Homeobox domain

  12. XM_063267339.1 → XP_063123409.1  POU domain, class 2, transcription factor 2 isoform X21

    UniProtKB/TrEMBL
    A0A8I6A6L7

  13. XM_063267045.1 → XP_063123115.1  POU domain, class 2, transcription factor 2 isoform X12

    Related
    ENSRNOP00000081328.2, ENSRNOT00000118587.2

  14. XM_063267312.1 → XP_063123382.1  POU domain, class 2, transcription factor 2 isoform X20

    UniProtKB/TrEMBL
    A0A8I6A6L7
    Related
    ENSRNOP00000101660.1, ENSRNOT00000137877.1

  15. XM_063267012.1 → XP_063123082.1  POU domain, class 2, transcription factor 2 isoform X11

  16. XM_017588682.3 → XP_017444171.1  POU domain, class 2, transcription factor 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A150

  17. XM_039113307.2 → XP_038969235.1  POU domain, class 2, transcription factor 2 isoform X16

    Conserved Domains (3) summary
    smart00352
    Location:327 → 401
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:231 → 348
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:432 → 486
    Homeobox; Homeobox domain

  18. XM_063267524.1 → XP_063123594.1  POU domain, class 2, transcription factor 2 isoform X27

    UniProtKB/TrEMBL
    A0A8I5ZSA9

  19. XM_017588689.3 → XP_017444178.1  POU domain, class 2, transcription factor 2 isoform X26

    UniProtKB/TrEMBL
    A0A8I5ZSA9

  20. XM_017588687.3 → XP_017444176.1  POU domain, class 2, transcription factor 2 isoform X19

    UniProtKB/TrEMBL
    A0A0G2KAN4
    Related
    ENSRNOP00000072745.3, ENSRNOT00000087572.3

  21. XM_063267218.1 → XP_063123288.1  POU domain, class 2, transcription factor 2 isoform X18

  22. XM_017588688.3 → XP_017444177.1  POU domain, class 2, transcription factor 2 isoform X22

    UniProtKB/TrEMBL
    A0A8I6A6L7

  23. XM_006228371.4 → XP_006228433.2  POU domain, class 2, transcription factor 2 isoform X23

    UniProtKB/TrEMBL
    A0A8I6A6L7
    Conserved Domains (2) summary
    smart00352
    Location:201 → 275
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:306 → 359
    Homeobox; Homeobox domain

  24. XM_063267183.1 → XP_063123253.1  POU domain, class 2, transcription factor 2 isoform X17

    UniProtKB/TrEMBL
    A0A0G2K3R5, A0A0G2KAN4

  25. XM_063267129.1 → XP_063123199.1  POU domain, class 2, transcription factor 2 isoform X15

  26. XM_006228372.4 → XP_006228434.2  POU domain, class 2, transcription factor 2 isoform X24

    See identical proteins and their annotated locations for XP_006228434.2

    UniProtKB/TrEMBL
    A0A8I6A6L7
    Conserved Domains (2) summary
    smart00352
    Location:195 → 269
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:300 → 353
    Homeobox; Homeobox domain

  27. XM_039113050.2 → XP_038968978.1  POU domain, class 2, transcription factor 2 isoform X3

    Conserved Domains (3) summary
    smart00352
    Location:315 → 389
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:219 → 336
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:420 → 474
    Homeobox; Homeobox domain

  28. XM_039113004.2 → XP_038968932.1  POU domain, class 2, transcription factor 2 isoform X2

    Conserved Domains (3) summary
    smart00352
    Location:324 → 398
    POU; Found in Pit-Oct-Unc transcription factors
    PRK10263
    Location:228 → 345
    PRK10263; DNA translocase FtsK; Provisional
    pfam00046
    Location:429 → 483
    Homeobox; Homeobox domain

  29. XM_039078078.2 → XP_038934006.1  POU domain, class 2, transcription factor 2 isoform X25

    UniProtKB/TrEMBL
    A0A8I6A6L7
    Conserved Domains (2) summary
    smart00352
    Location:195 → 269
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:300 → 354
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version

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