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WWP2 WW domain containing E3 ubiquitin protein ligase 2 [ Desmodus rotundus (common vampire bat) ]

Gene ID: 112300782, updated on 30-Mar-2024

Summary

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Gene symbol
WWP2
Gene description
WW domain containing E3 ubiquitin protein ligase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Desmodus rotundus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Phyllostomidae; Desmodontinae; Desmodus
Orthologs
human mouse all
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Genomic context

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See WWP2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_02 current HLdesRot8A (GCF_022682495.1) 12 NC_071398.1 (16495455..16643696)
101 previous assembly ASM294091v2 (GCF_002940915.1) Unplaced Scaffold NW_020090969.1 (15975424..16109738, complement)

Chromosome 12 - NC_071398.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene NAD(P)H quinone dehydrogenase 1 Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene proteasome 26S subunit, non-ATPase 7 Neighboring gene zinc finger homeobox 3 Neighboring gene uncharacterized LOC123479325

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP2
Names
Putative nedd4-like e3 ubiquitin-protein ligase wwp2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_022682495.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HLdesRot8A Primary Assembly

Genomic

  1. NC_071398.1 Reference HLdesRot8A Primary Assembly

    Range
    16495455..16643696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024556137.3 → XP_024411905.1  NEDD4-like E3 ubiquitin-protein ligase WWP2

    UniProtKB/TrEMBL
    K9J323
    Conserved Domains (5) summary
    cd04021
    Location:17 → 142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516 → 868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447 → 477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332 → 361
    WW; WW domain
    cl26464
    Location:152 → 304
    Atrophin-1; Atrophin-1 family

  2. XM_024556138.3 → XP_024411906.1  NEDD4-like E3 ubiquitin-protein ligase WWP2

    UniProtKB/TrEMBL
    K9J323
    Conserved Domains (5) summary
    cd04021
    Location:17 → 142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:516 → 868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:447 → 477
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:332 → 361
    WW; WW domain
    cl26464
    Location:152 → 304
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
Heading Accession and Version

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