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    KATNA1 katanin p60 (ATPase containing) subunit A 1 [ Homo sapiens ]

    Gene ID: 11104, updated on 20-May-2012

    Summary

    Official Symbol
    KATNA1provided by HGNC
    Official Full Name
    katanin p60 (ATPase containing) subunit A 1provided by HGNC
    Primary source
    HGNC:6216
    See related
    Ensembl:ENSG00000186625; HPRD:05986; MIM:606696; Vega:OTTHUMG00000015787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

    Genomic context

    Location :
    6q25.1
    Sequence :
    Chromosome: 6; NC_000006.11 (149916009..149969940, complement)
    See KATNA1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene chromosome 6 open reading frame 72 Neighboring gene ribosomal protein S18 pseudogene 9 Neighboring gene LATS, large tumor suppressor, homolog 1 (Drosophila) Neighboring gene uncharacterized LOC645967 Neighboring gene nucleoporin 43kDa

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O75449 Q9BVA0 KATNB1    HPRD  PubMed  
    O75449 Q05469 LIPE    HPRD  PubMed  
    BioGRID:116285 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116285 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:116285 BioGRID:114023 DYRK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:116285 BioGRID:121601 KLHDC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116285 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116285 BioGRID:119501 UBR5    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:116285 BioGRID:115079 VPRBP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    dynein binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to microtubule-severing ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
     
    interphase of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule severing IEA
    Inferred from Electronic Annotation
    more info
     
    mitosis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    lipid particle IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    katanin p60 ATPase-containing subunit A1
    Names
    katanin p60 ATPase-containing subunit A1
    p60 katanin
    katanin p60 subunit A1
    katanin p60 (ATPase-containing) subunit A 1
    NP_001191005.1
    NP_008975.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204076.1NP_001191005.1  katanin p60 ATPase-containing subunit A1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC050428, DB031858
      Consensus CDS
      CCDS56456.1
      UniProtKB/Swiss-Prot
      O75449
      Related
      ENSP00000335180, OTTHUMP00000042860, ENST00000335643, OTTHUMT00000105344
      Conserved Domains (2) summary
      cd00009
      Location:167305
      Blast Score: 250
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:167306
      Blast Score: 194
      AAA; ATPases associated with a variety of cellular activities
    2. NM_007044.3NP_008975.1  katanin p60 ATPase-containing subunit A1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK292090, BC050428, CA426364, DB031858
      Consensus CDS
      CCDS5217.1
      UniProtKB/TrEMBL
      A8K7S5
      UniProtKB/Swiss-Prot
      O75449
      Related
      ENSP00000356381, ENST00000367411
      Conserved Domains (4) summary
      cd00009
      Location:239381
      Blast Score: 255
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK04195
      Location:209265
      Blast Score: 96
      PRK04195; replication factor C large subunit; Provisional
      smart00382
      Location:241382
      Blast Score: 194
      AAA; ATPases associated with a variety of cellular activities
      pfam09336
      Location:456489
      Blast Score: 113
      Vps4_C; Vps4 C terminal oligomerisation domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      149916009..149969940, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      147482647..147536579, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL078581.11 CAI19504.1
      CAI19505.1
      CAI19506.1
      CAI19507.1
    genomic BX276089.8 CAI16431.1
      CAI16432.1
      CAI16433.1
      CAI16434.1
    genomic CH471051.2 EAW47793.1
      EAW47794.1
      EAW47795.1
    mRNA AF056022.1 AAC25114.1
    mRNA AK292090.1 BAF84779.1
    mRNA BC050428.1 AAH50428.1
    mRNA CA426364.1 None
    mRNA DB031858.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75449.1 GenPept UniProtKB/Swiss-Prot:O75449

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