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Cyld CYLD lysine 63 deubiquitinase [ Mus caroli (Ryukyu mouse) ]

Gene ID: 110299742, updated on 15-Mar-2024

Summary

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Gene symbol
Cyld
Gene description
CYLD lysine 63 deubiquitinase
See related
Ensembl:MGP_CAROLIEiJ_G0031361
Gene type
protein coding
RefSeq status
MODEL
Organism
Mus caroli
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
23
Annotation release Status Assembly Chr Location
101 current CAROLI_EIJ_v1.1 (GCF_900094665.1) 8 NC_034577.1 (80228999..80284925)

Chromosome 8 - NC_034577.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 20 Neighboring gene nucleotide binding oligomerization domain containing 2 Neighboring gene nucleophosmin pseudogene Neighboring gene uncharacterized LOC115031769 Neighboring gene spalt like transcription factor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_034577.1 Chromosome 8 Reference CAROLI_EIJ_v1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in necroptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase CYLD

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mus caroli Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CAROLI_EIJ_v1.1 Primary Assembly

Genomic

  1. NC_034577.1 Reference CAROLI_EIJ_v1.1 Primary Assembly

    Range
    80228999..80284925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029480370.1 → XP_029336230.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A0A6P7R6L2
    Related
    MGP_CAROLIEiJ_P0085481, MGP_CAROLIEiJ_T0085481.1

  2. XM_021169542.2 → XP_021025201.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A0A6P5Q5U2
    Related
    MGP_CAROLIEiJ_P0085479, MGP_CAROLIEiJ_T0085479.1
    Conserved Domains (3) summary
    smart01052
    Location:468 → 536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589 → 944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304 → 467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

  3. XM_029480372.1 → XP_029336232.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A0A6P7R6L2

  4. XM_029480374.1 → XP_029336234.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A0A6P7R6L2

  5. XM_029480375.1 → XP_029336235.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A0A6P7R6L2

  6. XM_029480371.1 → XP_029336231.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A0A6P7R6L2

  7. XM_029480376.1 → XP_029336236.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

    UniProtKB/TrEMBL
    A0A6P7RGK4

  8. XM_029480373.1 → XP_029336233.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A0A6P7R6L2
Nucleotide Protein
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