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TNK2 tyrosine kinase non receptor 2 [ Rousettus aegyptiacus (Egyptian rousette) ]

Gene ID: 107505259, updated on 30-Mar-2024

Summary

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Gene symbol
TNK2
Gene description
tyrosine kinase non receptor 2
Locus tag
HJG63_019659
Gene type
protein coding
RefSeq status
MODEL
Organism
Rousettus aegyptiacus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Rousettinae; Rousettus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
101 current mRouAeg1.p (GCF_014176215.1) Unplaced Scaffold NW_023416307.1 (50535015..50573714)
100 previous assembly Raegyp2.0 (GCF_001466805.2) Unplaced Scaffold NW_015493166.1 (1392320..1431032, complement)

NW_023416307.1Genomic Context describing neighboring genes Neighboring gene transferrin receptor Neighboring gene U2 spliceosomal RNA Neighboring gene ubiquitin-40S ribosomal protein S27a-like Neighboring gene mucin-4-like Neighboring gene 5S ribosomal RNA Neighboring gene putative protein TPRXL

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
activated CDC42 kinase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rousettus aegyptiacus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRouAeg1.p

Genomic

  1. NW_023416307.1 Reference mRouAeg1.p

    Range
    50535015..50573714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016135244.2 → XP_015990730.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A7J8HW62, A0A7J8HX70
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:975 → 1018
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1005 → 1044
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  2. XM_016135245.2 → XP_015990731.1  activated CDC42 kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A7J8HX70, A0A7J8HY24
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:960 → 1003
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:990 → 1029
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  3. XM_016135235.2 → XP_015990721.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A7J8HWE4
    Conserved Domains (8) summary
    cd09539
    Location:72 → 133
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:192 → 451
    STYKc; Protein kinase; unclassified specificity
    cd14274
    Location:1041 → 1084
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1071 → 1110
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:196 → 453
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:513 → 580
    GTPase_binding; GTPase binding
    pfam11555
    Location:855 → 919
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:461 → 510
    SH3_9; Variant SH3 domain

  4. XM_016135239.2 → XP_015990725.1  activated CDC42 kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A7J8HWE4, A0A7J8HXK9
    Conserved Domains (7) summary
    cd09539
    Location:72 → 133
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:1026 → 1069
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1056 → 1095
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:196 → 453
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:515 → 580
    GTPase_binding; GTPase binding
    pfam11555
    Location:840 → 904
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:461 → 510
    SH3_9; Variant SH3 domain

  5. XM_036219094.1 → XP_036074987.1  activated CDC42 kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A7J8HWE4
    Conserved Domains (5) summary
    cd09539
    Location:72 → 133
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd05040
    Location:196 → 453
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:515 → 580
    GTPase_binding; GTPase binding
    pfam11555
    Location:855 → 919
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:461 → 510
    SH3_9; Variant SH3 domain

  6. XM_036219093.1 → XP_036074986.1  activated CDC42 kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A7J8HX58
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:1007 → 1050
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1037 → 1076
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  7. XM_016135243.2 → XP_015990729.1  activated CDC42 kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A7J8HX58, A0A7J8HXL2
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:992 → 1035
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1022 → 1061
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  8. XM_036219096.1 → XP_036074989.1  activated CDC42 kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A7J8HX70, A0A7J8HX96
    Conserved Domains (6) summary
    cd14274
    Location:921 → 964
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:951 → 990
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:76 → 333
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:395 → 460
    GTPase_binding; GTPase binding
    pfam11555
    Location:735 → 799
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:341 → 390
    SH3_9; Variant SH3 domain
Nucleotide Protein
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