U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RAPGEF2 Rap guanine nucleotide exchange factor 2 [ Calidris pugnax (ruff) ]

Gene ID: 106889557, updated on 3-Aug-2024

Summary

Go to the top of the page Help
Gene symbol
RAPGEF2
Gene description
Rap guanine nucleotide exchange factor 2
See related
Ensembl:ENSCPUG00000006747
Gene type
protein coding
RefSeq status
MODEL
Organism
Calidris pugnax
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Scolopacidae; Calidris
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RAPGEF2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
33
Annotation release Status Assembly Chr Location
100 current ASM143184v1 (GCF_001431845.1) Unplaced Scaffold NW_015090774.1 (4112383..4314315, complement)

NW_015090774.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106890117 Neighboring gene endogenous retrovirus group K member 6 Pol protein-like Neighboring gene uncharacterized LOC106889008 Neighboring gene folliculin interacting protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NW_015090774.1 Unplaced Scaffold Reference ASM143184v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
rap guanine nucleotide exchange factor 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Calidris pugnax Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM143184v1

Genomic

  1. NW_015090774.1 Reference ASM143184v1

    Range
    4112383..4314315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014944711.1 → XP_014800197.1  rap guanine nucleotide exchange factor 2 isoform X2

    Related
    ENSCPUP00000009494.1, ENSCPUT00000011346.1
    Conserved Domains (7) summary
    smart00100
    Location:291 → 406
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:422 → 535
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    COG0664
    Location:31 → 147
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:37 → 143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:868 → 1093
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:539 → 619
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:761 → 845
    UBQ; Ubiquitin-like proteins

  2. XM_014944719.1 → XP_014800205.1  rap guanine nucleotide exchange factor 2 isoform X3

    Related
    ENSCPUP00000009484.1, ENSCPUT00000011333.1
    Conserved Domains (7) summary
    smart00100
    Location:297 → 412
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:428 → 541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    COG0664
    Location:31 → 147
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:37 → 143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:874 → 1099
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:545 → 625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:767 → 851
    UBQ; Ubiquitin-like proteins

  3. XM_014944726.1 → XP_014800212.1  rap guanine nucleotide exchange factor 2 isoform X4

    Related
    ENSCPUP00000009505.1, ENSCPUT00000011361.1
    Conserved Domains (5) summary
    smart00100
    Location:134 → 249
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:265 → 378
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:711 → 936
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:382 → 462
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:604 → 688
    UBQ; Ubiquitin-like proteins

  4. XM_014944735.1 → XP_014800221.1  rap guanine nucleotide exchange factor 2 isoform X5

    Related
    ENSCPUP00000009509.1, ENSCPUT00000011365.1
    Conserved Domains (5) summary
    smart00100
    Location:136 → 251
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:267 → 380
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:713 → 938
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:384 → 464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:606 → 690
    UBQ; Ubiquitin-like proteins

  5. XM_014944701.1 → XP_014800187.1  rap guanine nucleotide exchange factor 2 isoform X1

    Conserved Domains (5) summary
    smart00100
    Location:64 → 179
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:195 → 308
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:641 → 866
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:312 → 392
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:534 → 618
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.