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ITSN1 intersectin 1 [ Struthio camelus (African ostrich) ]

Gene ID: 104139448, updated on 23-Aug-2024

Summary

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Gene symbol
ITSN1
Gene description
intersectin 1
Locus tag
N308_11308
See related
Ensembl:ENSSCUG00000004162
Gene type
protein coding
RefSeq status
MODEL
Organism
Struthio camelus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae; Struthio
Orthologs
human mouse all
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Genomic context

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See ITSN1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
40
Annotation release Status Assembly Chr Location
100 current ASM69896v1 (GCF_000698965.1) Unplaced Scaffold NW_009270601.1 (1718274..1854479, complement)

NW_009270601.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104139447 Neighboring gene ATP synthase peripheral stalk subunit OSCP Neighboring gene crystallin zeta like 1 Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene SON DNA and RNA binding protein Neighboring gene phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_009270601.1 Unplaced Scaffold Reference ASM69896v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
intersectin-1
Names
Intersectin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Struthio camelus australis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM69896v1 Primary Assembly

Genomic

  1. NW_009270601.1 Reference ASM69896v1 Primary Assembly

    Range
    1718274..1854479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009667588.1 → XP_009665883.1  intersectin-1 isoform X1

    UniProtKB/TrEMBL
    A0A093H4R9
    Conserved Domains (18) summary
    cd08375
    Location:1578 → 1712
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11987
    Location:742 → 801
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:913 → 964
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:1002 → 1053
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:1070 → 1134
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:1154 → 1207
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00052
    Location:224 → 290
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:1444 → 1575
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:1461 → 1567
    PH; PH domain
    pfam00621
    Location:1238 → 1418
    RhoGEF; RhoGEF domain
    pfam13863
    Location:606 → 706
    DUF4200; Domain of unknown function (DUF4200)
    pfam13868
    Location:362 → 716
    TPH; Trichohyalin-plectin-homology domain
    pfam16617
    Location:801 → 913
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam17085
    Location:343 → 403
    UCMA; Unique cartilage matrix associated protein
    cd16269
    Location:467 → 478
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:369 → 499
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:546 → 647
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_009667590.1 → XP_009665885.1  intersectin-1 isoform X3

    UniProtKB/TrEMBL
    A0A093H4R9
    Related
    ENSSCUP00000005626.1, ENSSCUT00000007458.1
    Conserved Domains (18) summary
    cd08375
    Location:1513 → 1647
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:153 → 248
    EH; Eps15 homology domain
    cd11987
    Location:682 → 736
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:848 → 899
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:937 → 988
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:1005 → 1069
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:1089 → 1142
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00052
    Location:164 → 230
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:1379 → 1510
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:1396 → 1502
    PH; PH domain
    pfam00621
    Location:1173 → 1353
    RhoGEF; RhoGEF domain
    pfam13868
    Location:302 → 656
    TPH; Trichohyalin-plectin-homology domain
    pfam16617
    Location:736 → 848
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam17085
    Location:283 → 343
    UCMA; Unique cartilage matrix associated protein
    cd16269
    Location:407 → 418
    GBP_C; coiled coil [structural motif]
    cl00583
    Location:548 → 642
    PhaG_MnhG_YufB; Na+/H+ antiporter subunit
    cl20817
    Location:309 → 439
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:486 → 587
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_009667589.1 → XP_009665884.1  intersectin-1 isoform X2

    UniProtKB/TrEMBL
    A0A093H4R9
    Related
    ENSSCUP00000005623.1, ENSSCUT00000007455.1
    Conserved Domains (18) summary
    cd08375
    Location:1573 → 1707
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11987
    Location:742 → 796
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:908 → 959
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:997 → 1048
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:1065 → 1129
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:1149 → 1202
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00052
    Location:224 → 290
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:1439 → 1570
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:1456 → 1562
    PH; PH domain
    pfam00621
    Location:1233 → 1413
    RhoGEF; RhoGEF domain
    pfam13863
    Location:606 → 706
    DUF4200; Domain of unknown function (DUF4200)
    pfam13868
    Location:362 → 716
    TPH; Trichohyalin-plectin-homology domain
    pfam16617
    Location:796 → 908
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam17085
    Location:343 → 403
    UCMA; Unique cartilage matrix associated protein
    cd16269
    Location:467 → 478
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:369 → 499
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:546 → 647
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version

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