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TOP2B DNA topoisomerase II beta [ Nipponia nippon (crested ibis) ]

Gene ID: 104013961, updated on 3-Aug-2024

Summary

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Gene symbol
TOP2B
Gene description
DNA topoisomerase II beta
Locus tag
Y956_04148
Gene type
protein coding
RefSeq status
MODEL
Organism
Nipponia nippon
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Pelecaniformes; Threskiornithidae; Nipponia
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
40
Annotation release Status Assembly Chr Location
100 current ASM70822v1 (GCF_000708225.1) Unplaced Scaffold NW_009000920.1 (3323154..3403286)

NW_009000920.1Genomic Context describing neighboring genes Neighboring gene N-glycanase 1 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial Neighboring gene retinoic acid receptor beta Neighboring gene thyroid hormone receptor beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_009000920.1 Unplaced Scaffold Reference ASM70822v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase 2-beta
Names
topoisomerase (DNA) II beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nipponia nippon Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM70822v1 Primary Assembly

Genomic

  1. NW_009000920.1 Reference ASM70822v1 Primary Assembly

    Range
    3323154..3403286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009466539.1 → XP_009464814.1  DNA topoisomerase 2-beta

    UniProtKB/TrEMBL
    A0A091V4C9
    Conserved Domains (7) summary
    cd03365
    Location:577 → 697
    TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
    cd00187
    Location:833 → 1293
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    cd03481
    Location:387 → 539
    TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
    PTZ00108
    Location:147 → 1573
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam02518
    Location:202 → 299
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    pfam08070
    Location:1616 → 1709
    DTHCT; DTHCT (NUC029) region
    pfam16898
    Location:695 → 833
    TOPRIM_C; C-terminal associated domain of TOPRIM
Nucleotide Protein
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