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APC APC regulator of WNT signaling pathway [ Chlorocebus sabaeus (green monkey) ]

Gene ID: 103244338, updated on 11-Mar-2024

Summary

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Gene symbol
APC
Gene description
APC regulator of WNT signaling pathway
See related
Ensembl:ENSCSAG00000014935
Gene type
protein coding
RefSeq status
MODEL
Organism
Chlorocebus sabaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666034.1 (62320613..62469122, complement)
100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 23 NC_023664.1 (15992437..16135117)

NW_023666034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119627901 Neighboring gene putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 Neighboring gene uncharacterized LOC103245147 Neighboring gene receptor accessory protein 5 Neighboring gene signal recognition particle 19 Neighboring gene U6 spliceosomal RNA Neighboring gene chromobox protein homolog 3-like Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene small nucleolar RNA SNORA13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables gamma-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adenomatous polyposis coli protein
Names
APC, WNT signaling pathway regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Vero_WHO_p1.0

Genomic

  1. NW_023666034.1 Reference Vero_WHO_p1.0

    Range
    62320613..62469122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008014146.2 → XP_008012337.2  adenomatous polyposis coli protein isoform X9

    Conserved Domains (15) summary
    smart00185
    Location:541 → 581
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:455 → 487
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 623
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1529 → 1552
    APC_r; APC repeat
    pfam05924
    Location:1926 → 1945
    SAMP; SAMP Motif
    pfam05937
    Location:2563 → 2735
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2116 → 2461
    APC_basic; APC basic domain
    pfam11414
    Location:102 → 182
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:624 → 911
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:928 → 1027
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1175 → 1260
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1554 → 1607
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1638 → 1731
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1765 → 1839
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:282 → 340
    APC_rep; Adenomatous polyposis coli (APC) repeat

  2. XM_038008979.1 → XP_037864907.1  adenomatous polyposis coli protein isoform X1

    Conserved Domains (15) summary
    smart00185
    Location:642 → 682
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:556 → 588
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:684 → 724
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1630 → 1653
    APC_r; APC repeat
    pfam05924
    Location:2027 → 2046
    SAMP; SAMP Motif
    pfam05937
    Location:2664 → 2836
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2217 → 2562
    APC_basic; APC basic domain
    pfam11414
    Location:102 → 182
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:725 → 1012
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1029 → 1128
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1276 → 1361
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1655 → 1708
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1739 → 1832
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1866 → 1940
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:368 → 441
    APC_rep; Adenomatous polyposis coli (APC) repeat

  3. XM_008014148.2 → XP_008012339.1  adenomatous polyposis coli protein isoform X6

    Conserved Domains (13) summary
    cd00020
    Location:621 → 741
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1647 → 1671
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2045 → 2064
    SAMP; SAMP Motif
    pfam05937
    Location:2681 → 2853
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2234 → 2579
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:742 → 1029
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1046 → 1145
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1293 → 1378
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1672 → 1728
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1749 → 1849
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1886 → 1957
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:475 → 518
    ARM; armadillo repeat [structural motif]

  4. XM_008014142.2 → XP_008012333.1  adenomatous polyposis coli protein isoform X8

    See identical proteins and their annotated locations for XP_008012333.1

    Conserved Domains (14) summary
    cd00020
    Location:611 → 731
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1637 → 1661
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2035 → 2054
    SAMP; SAMP Motif
    pfam05937
    Location:2671 → 2843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2224 → 2569
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:732 → 1019
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1036 → 1135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1283 → 1368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1662 → 1718
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1739 → 1839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1876 → 1947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]

  5. XM_038009020.1 → XP_037864948.1  adenomatous polyposis coli protein isoform X11

    Conserved Domains (15) summary
    smart00185
    Location:558 → 598
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:374 → 417
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:600 → 640
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1546 → 1569
    APC_r; APC repeat
    pfam05924
    Location:1943 → 1962
    SAMP; SAMP Motif
    pfam05937
    Location:2580 → 2752
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2133 → 2478
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:641 → 928
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:945 → 1044
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1192 → 1277
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1571 → 1624
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1655 → 1748
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1782 → 1856
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:317 → 375
    APC_rep; Adenomatous polyposis coli (APC) repeat

  6. XM_008014137.2 → XP_008012328.1  adenomatous polyposis coli protein isoform X4

    Conserved Domains (14) summary
    cd00020
    Location:633 → 753
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1659 → 1683
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2057 → 2076
    SAMP; SAMP Motif
    pfam05937
    Location:2693 → 2865
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2246 → 2591
    APC_basic; APC basic domain
    pfam09786
    Location:2272 → 2525
    CytochromB561_N; Cytochrome B561, N terminal
    pfam11414
    Location:131 → 211
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:754 → 1041
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1058 → 1157
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1305 → 1390
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1684 → 1740
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1761 → 1861
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1898 → 1969
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:585 → 617
    ARM; armadillo repeat [structural motif]

  7. XM_038009017.1 → XP_037864945.1  adenomatous polyposis coli protein isoform X10

    Conserved Domains (15) summary
    smart00185
    Location:588 → 628
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:404 → 447
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:630 → 670
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1576 → 1599
    APC_r; APC repeat
    pfam05924
    Location:1973 → 1992
    SAMP; SAMP Motif
    pfam05937
    Location:2610 → 2782
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2163 → 2508
    APC_basic; APC basic domain
    pfam11414
    Location:167 → 247
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:671 → 958
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:975 → 1074
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1222 → 1307
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1601 → 1654
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1685 → 1778
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1812 → 1886
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:347 → 405
    APC_rep; Adenomatous polyposis coli (APC) repeat

  8. XM_008014135.2 → XP_008012326.1  adenomatous polyposis coli protein isoform X2

    Conserved Domains (14) summary
    cd00020
    Location:651 → 771
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1677 → 1701
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2075 → 2094
    SAMP; SAMP Motif
    pfam05937
    Location:2711 → 2883
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2264 → 2609
    APC_basic; APC basic domain
    pfam09786
    Location:2290 → 2543
    CytochromB561_N; Cytochrome B561, N terminal
    pfam11414
    Location:167 → 247
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:772 → 1059
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1076 → 1175
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1323 → 1408
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1702 → 1758
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1779 → 1879
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1916 → 1987
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:505 → 548
    ARM; armadillo repeat [structural motif]

  9. XM_038009025.1 → XP_037864953.1  adenomatous polyposis coli protein isoform X12

    Conserved Domains (15) summary
    smart00185
    Location:552 → 592
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368 → 411
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:594 → 634
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1540 → 1563
    APC_r; APC repeat
    pfam05924
    Location:1937 → 1956
    SAMP; SAMP Motif
    pfam05937
    Location:2574 → 2746
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2127 → 2472
    APC_basic; APC basic domain
    pfam11414
    Location:131 → 211
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:635 → 922
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:939 → 1038
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1186 → 1271
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1565 → 1618
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1649 → 1742
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1776 → 1850
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:311 → 369
    APC_rep; Adenomatous polyposis coli (APC) repeat

  10. XM_038009000.1 → XP_037864928.1  adenomatous polyposis coli protein isoform X7

    Conserved Domains (15) summary
    smart00185
    Location:653 → 693
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:469 → 512
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:695 → 735
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1641 → 1664
    APC_r; APC repeat
    pfam05924
    Location:2038 → 2057
    SAMP; SAMP Motif
    pfam05937
    Location:2675 → 2847
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2228 → 2573
    APC_basic; APC basic domain
    pfam11414
    Location:131 → 211
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:736 → 1023
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1040 → 1139
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1287 → 1372
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1666 → 1719
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1750 → 1843
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1877 → 1951
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:397 → 470
    APC_rep; Adenomatous polyposis coli (APC) repeat

  11. XM_008014140.2 → XP_008012331.1  adenomatous polyposis coli protein isoform X5

    See identical proteins and their annotated locations for XP_008012331.1

    UniProtKB/TrEMBL
    A0A0D9RR03
    Conserved Domains (16) summary
    smart00185
    Location:667 → 707
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:581 → 613
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:709 → 749
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1655 → 1678
    APC_r; APC repeat
    pfam05924
    Location:2052 → 2071
    SAMP; SAMP Motif
    pfam05937
    Location:2689 → 2861
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2242 → 2587
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:750 → 1037
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1054 → 1153
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1301 → 1386
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1680 → 1733
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1764 → 1857
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1891 → 1965
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:393 → 466
    APC_rep; Adenomatous polyposis coli (APC) repeat

  12. XM_038009030.1 → XP_037864958.1  adenomatous polyposis coli protein isoform X13

    Conserved Domains (16) summary
    smart00185
    Location:548 → 588
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:364 → 407
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:590 → 630
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1536 → 1559
    APC_r; APC repeat
    pfam05924
    Location:1933 → 1952
    SAMP; SAMP Motif
    pfam05937
    Location:2570 → 2742
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2123 → 2468
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:631 → 918
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:935 → 1034
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1182 → 1267
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1561 → 1614
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1645 → 1738
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1772 → 1846
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:307 → 365
    APC_rep; Adenomatous polyposis coli (APC) repeat

  13. XM_008014143.2 → XP_008012334.1  adenomatous polyposis coli protein isoform X8

    See identical proteins and their annotated locations for XP_008012334.1

    Conserved Domains (14) summary
    cd00020
    Location:611 → 731
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1637 → 1661
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2035 → 2054
    SAMP; SAMP Motif
    pfam05937
    Location:2671 → 2843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2224 → 2569
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:732 → 1019
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1036 → 1135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1283 → 1368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1662 → 1718
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1739 → 1839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1876 → 1947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]

  14. XM_008014145.2 → XP_008012336.1  adenomatous polyposis coli protein isoform X8

    See identical proteins and their annotated locations for XP_008012336.1

    Conserved Domains (14) summary
    cd00020
    Location:611 → 731
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1637 → 1661
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2035 → 2054
    SAMP; SAMP Motif
    pfam05937
    Location:2671 → 2843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2224 → 2569
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:732 → 1019
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1036 → 1135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1283 → 1368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1662 → 1718
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1739 → 1839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1876 → 1947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]

  15. XM_008014139.2 → XP_008012330.1  adenomatous polyposis coli protein isoform X5

    See identical proteins and their annotated locations for XP_008012330.1

    UniProtKB/TrEMBL
    A0A0D9RR03
    Related
    ENSCSAP00000011042.1
    Conserved Domains (16) summary
    smart00185
    Location:667 → 707
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:581 → 613
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:709 → 749
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1655 → 1678
    APC_r; APC repeat
    pfam05924
    Location:2052 → 2071
    SAMP; SAMP Motif
    pfam05937
    Location:2689 → 2861
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2242 → 2587
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:750 → 1037
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1054 → 1153
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1301 → 1386
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1680 → 1733
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1764 → 1857
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1891 → 1965
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:393 → 466
    APC_rep; Adenomatous polyposis coli (APC) repeat

  16. XM_008014136.2 → XP_008012327.1  adenomatous polyposis coli protein isoform X3

    Conserved Domains (13) summary
    cd00020
    Location:639 → 759
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1665 → 1689
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2063 → 2082
    SAMP; SAMP Motif
    pfam05937
    Location:2699 → 2871
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2252 → 2597
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:760 → 1047
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1064 → 1163
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1311 → 1396
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1690 → 1746
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1767 → 1867
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1904 → 1975
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:591 → 623
    ARM; armadillo repeat [structural motif]

  17. XM_038008998.1 → XP_037864926.1  adenomatous polyposis coli protein isoform X5

    UniProtKB/TrEMBL
    A0A0D9RR03
    Conserved Domains (16) summary
    smart00185
    Location:667 → 707
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:581 → 613
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:709 → 749
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1655 → 1678
    APC_r; APC repeat
    pfam05924
    Location:2052 → 2071
    SAMP; SAMP Motif
    pfam05937
    Location:2689 → 2861
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2242 → 2587
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:750 → 1037
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1054 → 1153
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1301 → 1386
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1680 → 1733
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1764 → 1857
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1891 → 1965
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:393 → 466
    APC_rep; Adenomatous polyposis coli (APC) repeat

  18. XM_008014141.2 → XP_008012332.1  adenomatous polyposis coli protein isoform X5

    See identical proteins and their annotated locations for XP_008012332.1

    UniProtKB/TrEMBL
    A0A0D9RR03
    Conserved Domains (16) summary
    smart00185
    Location:667 → 707
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:581 → 613
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:709 → 749
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1655 → 1678
    APC_r; APC repeat
    pfam05924
    Location:2052 → 2071
    SAMP; SAMP Motif
    pfam05937
    Location:2689 → 2861
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2242 → 2587
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:750 → 1037
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1054 → 1153
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1301 → 1386
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1680 → 1733
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1764 → 1857
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1891 → 1965
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:393 → 466
    APC_rep; Adenomatous polyposis coli (APC) repeat
Nucleotide Protein
Heading Accession and Version

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