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ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Lipotes vexillifer (Yangtze River dolphin) ]

Gene ID: 103081507, updated on 11-Mar-2024

Summary

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Gene symbol
ROCK2
Gene description
Rho associated coiled-coil containing protein kinase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Lipotes vexillifer
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Lipotidae; Lipotes
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
34
Annotation release Status Assembly Chr Location
100 current Lipotes_vexillifer_v1 (GCF_000442215.1) Unplaced Scaffold NW_006784503.1 (2399200..2533953)

NW_006784503.1Genomic Context describing neighboring genes Neighboring gene FMR1 autosomal homolog 1-like Neighboring gene E2F transcription factor 6 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene pantothenate kinase 3-like Neighboring gene solute carrier family 66 member 3 Neighboring gene ciliary microtubule inner protein 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006784503 unplaced scaffold reference Lipotes_vexillifer_v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho-associated protein kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Lipotes vexillifer Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Lipotes_vexillifer_v1 Primary Assembly

Genomic

  1. NW_006784503.1 Reference Lipotes_vexillifer_v1 Primary Assembly

    Range
    2399200..2533953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007456912.1 → XP_007456974.1  rho-associated protein kinase 2

    UniProtKB/TrEMBL
    A0A340XCM7
    Conserved Domains (7) summary
    cd11638
    Location:496 → 562
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:83 → 345
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:428 → 1092
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1252 → 1298
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1142 → 1248
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:30 → 408
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    pfam08912
    Location:970 → 1037
    Rho_Binding; Rho Binding

  2. XM_007456911.1 → XP_007456973.1  rho-associated protein kinase 2

    UniProtKB/TrEMBL
    A0A340X5X9
    Conserved Domains (7) summary
    cd11638
    Location:496 → 562
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:83 → 345
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:428 → 1092
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1252 → 1298
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1142 → 1248
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:30 → 408
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    pfam08912
    Location:970 → 1037
    Rho_Binding; Rho Binding
Nucleotide Protein
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