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DUSP6 dual specificity phosphatase 6 [ Alligator mississippiensis (American alligator) ]

Gene ID: 102567008, updated on 8-May-2024

Summary

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Gene symbol
DUSP6
Gene description
dual specificity phosphatase 6
Locus tag
Y1Q_0020026
See related
EnsemblRapid:ENSAMIG00015009071
Gene type
protein coding
RefSeq status
MODEL
Organism
Alligator mississippiensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; Alligator
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_09 current rAllMis1 (GCF_030867095.1) 4 NC_081827.1 (85252598..85257806, complement)
102 previous assembly ASM28112v4 (GCF_000281125.3) Unplaced Scaffold NW_017714414.1 (4079405..4084700, complement)

Chromosome 4 - NC_081827.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132249829 Neighboring gene POC1 centriolar protein B Neighboring gene uncharacterized LOC109281516 Neighboring gene ATPase plasma membrane Ca2+ transporting 1 Neighboring gene uncharacterized LOC109281500

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of heart growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein phosphatase 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030867095.1-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference rAllMis1 Primary Assembly

Genomic

  1. NC_081827.1 Reference rAllMis1 Primary Assembly

    Range
    85252598..85257806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006268625.4 → XP_006268687.1  dual specificity protein phosphatase 6

    UniProtKB/TrEMBL
    A0A151LYT1
    Related
    ENSAMIP00015011018.1, ENSAMIT00015016275.1
    Conserved Domains (3) summary
    COG2453
    Location:205 → 358
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:208 → 345
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:17 → 148
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
Nucleotide Protein
Heading Accession and Version

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