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PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Vicugna pacos (alpaca) ]

Gene ID: 102543068, updated on 10-Mar-2024

Summary

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Gene symbol
PIK3CA
Gene description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Gene type
protein coding
RefSeq status
MODEL
Organism
Vicugna pacos
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Vicugna
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
20
Annotation release Status Assembly Chr Location
102 current VicPac3.1 (GCF_000164845.3) 1 Unlocalized Scaffold NW_021964156.1 (4193959..4222751)
101 previous assembly Vicugna_pacos-2.0.1 (GCF_000164845.1) Unplaced Scaffold NW_005882816.1 (3639438..3665030)

NW_021964156.1Genomic Context describing neighboring genes Neighboring gene zinc finger matrin-type 3 Neighboring gene U6 spliceosomal RNA Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene zinc finger protein 639

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Vicugna pacos Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference VicPac3.1 Primary Assembly

Genomic

  1. NW_021964156.1 Reference VicPac3.1 Primary Assembly

    Range
    4193959..4222751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006210611.3 → XP_006210673.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    See identical proteins and their annotated locations for XP_006210673.1

    UniProtKB/TrEMBL
    A0A6I9IFN7
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:525 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:695 → 1064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain
Nucleotide Protein
Heading Accession and Version

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