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HGF hepatocyte growth factor [ Bos mutus (wild yak) ]

Gene ID: 102267837, updated on 10-Mar-2024

Summary

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Gene symbol
HGF
Gene description
hepatocyte growth factor
Locus tag
M91_06788
See related
Ensembl:ENSBMUG00000017715
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos mutus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
101 current BosGru_v2.0 (GCF_000298355.1) Unplaced Scaffold NW_005393180.1 (1514578..1596655, complement)

NW_005393180.1Genomic Context describing neighboring genes Neighboring gene semaphorin 3C Neighboring gene nucleosome assembly protein 1-like 1 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene piccolo presynaptic cytomatrix protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_005393180.1 Unplaced Scaffold Reference BosGru_v2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bos mutus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BosGru_v2.0 Primary Assembly

Genomic

  1. NW_005393180.1 Reference BosGru_v2.0 Primary Assembly

    Range
    1514578..1596655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005890241.1 → XP_005890303.1  hepatocyte growth factor isoform X2

    See identical proteins and their annotated locations for XP_005890303.1

    UniProtKB/TrEMBL
    L8IY98
    Related
    ENSBMUP00000023642.1, ENSBMUT00000027221.1
    Conserved Domains (4) summary
    smart00020
    Location:494 → 718
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:210 → 288
    KR; Kringle domain
    cd00108
    Location:302 → 384
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:40 → 122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

  2. XM_005890242.2 → XP_005890304.1  hepatocyte growth factor isoform X3

    See identical proteins and their annotated locations for XP_005890304.1

    UniProtKB/TrEMBL
    L8IY98
    Conserved Domains (4) summary
    smart00020
    Location:489 → 713
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:205 → 283
    KR; Kringle domain
    cd00108
    Location:297 → 379
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:40 → 122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

  3. XM_014476515.1 → XP_014332001.1  hepatocyte growth factor isoform X1

    UniProtKB/TrEMBL
    L8IY98
    Conserved Domains (5) summary
    smart00020
    Location:496 → 720
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:205 → 284
    KR; Kringle domain
    cd00108
    Location:304 → 386
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:40 → 122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:497 → 723
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. XR_314783.1 RNA Sequence

  2. XR_314782.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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