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CDC42BPA CDC42 binding protein kinase alpha [ Felis catus (domestic cat) ]

Gene ID: 101088047, updated on 17-Aug-2024

Summary

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Official Symbol
CDC42BPA
Official Full Name
CDC42 binding protein kinase alpha
Primary source
VGNC:VGNC:60657
See related
EnsemblRapid:ENSFCTG00005008688
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: F1
Exon count:
41
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) F1 NC_058384.1 (2756371..3078074, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) F1 NC_018739.3 (4776150..5101245, complement)

Chromosome F1 - NC_058384.1Genomic Context describing neighboring genes Neighboring gene presenilin 2 Neighboring gene uncharacterized LOC123382935 Neighboring gene coenzyme Q8A Neighboring gene uncharacterized LOC109495432 Neighboring gene uncharacterized LOC102900418

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actomyosin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058384.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    2756371..3078074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019821471.3 → XP_019677030.2  serine/threonine-protein kinase MRCK alpha isoform X9

    UniProtKB/TrEMBL
    A0A2I2UU64
    Conserved Domains (6) summary
    COG0419
    Location:372 → 872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1018 → 1152
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:5 → 335
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:1178 → 1442
    CNH; CNH domain
    pfam15796
    Location:460 → 538
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:957 → 1016
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  2. XM_011290821.4 → XP_011289123.2  serine/threonine-protein kinase MRCK alpha isoform X15

    UniProtKB/TrEMBL
    A0A2I2UYY3
    Related
    ENSFCTP00005016408.1, ENSFCTT00005025158.1
    Conserved Domains (6) summary
    pfam08826
    Location:800 → 860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442 → 861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:978 → 1112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1138 → 1402
    CNH; CNH domain
    cd20864
    Location:917 → 976
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  3. XM_019821472.3 → XP_019677031.2  serine/threonine-protein kinase MRCK alpha isoform X11

    UniProtKB/TrEMBL
    A0A2I2UYY3
    Conserved Domains (6) summary
    pfam08826
    Location:800 → 860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442 → 861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1007 → 1141
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1167 → 1431
    CNH; CNH domain
    cd20864
    Location:946 → 1005
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  4. XM_019821474.3 → XP_019677033.2  serine/threonine-protein kinase MRCK alpha isoform X14

    UniProtKB/TrEMBL
    A0A2I2UH19
    Related
    ENSFCTP00005016254.1, ENSFCTT00005024939.1
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1039 → 1173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1199 → 1463
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:978 → 1037
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  5. XM_019821470.3 → XP_019677029.2  serine/threonine-protein kinase MRCK alpha isoform X7

    UniProtKB/TrEMBL
    A0A2I2UH19, A0A337SW71
    Conserved Domains (6) summary
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1039 → 1173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1199 → 1463
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:978 → 1037
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  6. XM_019821469.3 → XP_019677028.2  serine/threonine-protein kinase MRCK alpha isoform X6

    UniProtKB/TrEMBL
    M3WA87
    Conserved Domains (6) summary
    COG0419
    Location:442 → 943
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1049 → 1183
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1209 → 1473
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:988 → 1047
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  7. XM_019821468.3 → XP_019677027.2  serine/threonine-protein kinase MRCK alpha isoform X4

    UniProtKB/TrEMBL
    A0A337S4S9
    Conserved Domains (6) summary
    COG0419
    Location:442 → 943
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1062 → 1196
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1222 → 1486
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1001 → 1060
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  8. XM_011290820.4 → XP_011289122.2  serine/threonine-protein kinase MRCK alpha isoform X12

    UniProtKB/TrEMBL
    M3WA87
    Related
    ENSFCTP00005015906.1, ENSFCTT00005024432.1
    Conserved Domains (6) summary
    COG0419
    Location:442 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1059 → 1193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1219 → 1483
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:998 → 1057
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  9. XM_011290817.4 → XP_011289119.2  serine/threonine-protein kinase MRCK alpha isoform X5

    UniProtKB/TrEMBL
    M3WA87
    Related
    ENSFCTP00005016049.1, ENSFCTT00005024652.1
    Conserved Domains (6) summary
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1059 → 1193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1219 → 1483
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:998 → 1057
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  10. XM_045049425.1 → XP_044905360.1  serine/threonine-protein kinase MRCK alpha isoform X17

    UniProtKB/TrEMBL
    A0A2I2UU64
    Conserved Domains (6) summary
    smart00109
    Location:1035 → 1084
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00285
    Location:1593 → 1627
    PBD; P21-Rho-binding domain
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1094 → 1228
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    cl02434
    Location:1257 → 1512
    CNH; CNH domain

  11. XM_011290819.4 → XP_011289121.2  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    A0A337S4S9
    Related
    ENSFCTP00005016152.1, ENSFCTT00005024813.1
    Conserved Domains (6) summary
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1072 → 1206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1232 → 1496
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1011 → 1070
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  12. XM_011290816.4 → XP_011289118.2  serine/threonine-protein kinase MRCK alpha isoform X3

    UniProtKB/TrEMBL
    A0A337S4S9
    Conserved Domains (6) summary
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1072 → 1206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1232 → 1496
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1011 → 1070
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  13. XM_019821467.3 → XP_019677026.2  serine/threonine-protein kinase MRCK alpha isoform X2

    UniProtKB/TrEMBL
    A0A337S7S1
    Conserved Domains (6) summary
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1075 → 1209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1235 → 1499
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1014 → 1073
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  14. XM_011290818.4 → XP_011289120.2  serine/threonine-protein kinase MRCK alpha isoform X8

    UniProtKB/TrEMBL
    A0A2I2UU64
    Related
    ENSFCTP00005016075.1, ENSFCTT00005024695.1
    Conserved Domains (6) summary
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1088 → 1222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1248 → 1512
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1027 → 1086
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  15. XM_019821465.3 → XP_019677024.2  serine/threonine-protein kinase MRCK alpha isoform X1

    UniProtKB/TrEMBL
    A0A2I2UU64, A0A337S9M3
    Conserved Domains (6) summary
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1088 → 1222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1248 → 1512
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1027 → 1086
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  16. XM_045049424.1 → XP_044905359.1  serine/threonine-protein kinase MRCK alpha isoform X16

    UniProtKB/TrEMBL
    A0A2I2UU64
    Conserved Domains (5) summary
    smart00109
    Location:1064 → 1113
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    COG0419
    Location:442 → 942
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1123 → 1257
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    cl02434
    Location:1286 → 1541
    CNH; CNH domain

  17. XM_045049423.1 → XP_044905358.1  serine/threonine-protein kinase MRCK alpha isoform X13

    UniProtKB/TrEMBL
    A0A2I2UU64
    Conserved Domains (6) summary
    smart00109
    Location:925 → 974
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    COG0419
    Location:338 → 838
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00132
    Location:1481 → 1508
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:984 → 1118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1 → 301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl02434
    Location:1147 → 1402
    CNH; CNH domain
Nucleotide Protein
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