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F2 coagulation factor II, thrombin [ Canis lupus familiaris (dog) ]

Gene ID: 100856539, updated on 8-Mar-2024

Summary

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Official Symbol
F2provided by VGNC
Official Full Name
coagulation factor II, thrombinprovided by VGNC
Primary source
VGNC:VGNC:40547
See related
Ensembl:ENSCAFG00845026955
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (43438760..43455850, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (41511662..41528485, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (43208980..43225802, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (42924063..42940888, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (42479219..42496510, complement)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 4 Neighboring gene uncharacterized LOC119864228 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA SNORD67 Neighboring gene zinc finger protein 408 Neighboring gene Rho GTPase activating protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prothrombin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    43438760..43455850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038424479.1 → XP_038280407.1  prothrombin

    UniProtKB/TrEMBL
    A0A8C0L406, A0A8C0PX10, A0A8I3PUT1
    Related
    ENSCAFP00845037271.1, ENSCAFT00845047500.1
    Conserved Domains (5) summary
    smart00069
    Location:23 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:213 → 293
    KR; Kringle domain
    cd00108
    Location:104 → 185
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:363 → 615
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:316 → 362
    Thrombin_light; Thrombin light chain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    42924063..42940888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500763.1 → XP_038356691.1  prothrombin

    Conserved Domains (5) summary
    smart00069
    Location:23 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:213 → 293
    KR; Kringle domain
    cd00108
    Location:104 → 185
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:363 → 615
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:316 → 362
    Thrombin_light; Thrombin light chain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    42479219..42496510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038627526.1 → XP_038483454.1  prothrombin

    Conserved Domains (5) summary
    smart00069
    Location:23 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:213 → 293
    KR; Kringle domain
    cd00108
    Location:104 → 185
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:363 → 615
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:316 → 362
    Thrombin_light; Thrombin light chain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    43208980..43225802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038563408.1 → XP_038419336.1  prothrombin

    UniProtKB/TrEMBL
    A0A8C0L406, A0A8C0PX10, A0A8I3PUT1
    Conserved Domains (5) summary
    smart00069
    Location:23 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:213 → 293
    KR; Kringle domain
    cd00108
    Location:104 → 185
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:363 → 615
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:316 → 362
    Thrombin_light; Thrombin light chain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    41511662..41528485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003639694.5 → XP_003639742.1  prothrombin

    UniProtKB/TrEMBL
    A0A8C0L406, A0A8C0PX10, A0A8I3PUT1
    Conserved Domains (5) summary
    smart00069
    Location:23 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:213 → 293
    KR; Kringle domain
    cd00108
    Location:104 → 185
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:363 → 615
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:316 → 362
    Thrombin_light; Thrombin light chain
Nucleotide Protein
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