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F2 coagulation factor II [ Mus musculus (house mouse) ]

Gene ID: 14061, updated on 23-May-2018
Official Symbol
F2provided by MGI
Official Full Name
coagulation factor IIprovided by MGI
Primary source
MGI:MGI:88380
See related
Ensembl:ENSMUSG00000027249 Vega:OTTMUSG00000014282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cf2; FII; Cf-2
Summary
This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]
Expression
Biased expression in liver adult (RPKM 695.9), liver E18 (RPKM 621.7) and 3 other tissues See more
Orthologs
Location:
2 E1; 2 50.63 cM
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (91613986..91636457, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91465477..91476571, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13770 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA, C/D box 67 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene zinc finger protein 408 Neighboring gene Rho GTPase activating protein 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
thrombospondin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood coagulation ISO
Inferred from Sequence Orthology
more info
 
blood coagulation, fibrin clot formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cytolysis by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
 
fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
neutrophil mediated killing of gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
prothrombin
Names
thrombin
NP_034298.1
XP_011237590.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010168.3NP_034298.1  prothrombin preproprotein

    See identical proteins and their annotated locations for NP_034298.1

    Status: REVIEWED

    Source sequence(s)
    AK167532, BY705183, X52308
    Consensus CDS
    CCDS16434.1
    UniProtKB/Swiss-Prot
    P19221
    UniProtKB/TrEMBL
    Q3TJ94
    Related
    ENSMUSP00000028681.8, ENSMUST00000028681.14
    Conserved Domains (5) summary
    smart00020
    Location:360610
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:2589
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:107189
    KR; Kringle domain
    cd00190
    Location:361613
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:313360
    Thrombin_light; Thrombin light chain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    91613986..91636457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239288.1XP_011237590.1  prothrombin isoform X1

    Conserved Domains (5) summary
    smart00020
    Location:360575
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:2589
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:107189
    KR; Kringle domain
    cd00190
    Location:361572
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:313360
    Thrombin_light; Thrombin light chain
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