F2 coagulation factor II, thrombin [Homo sapiens (human)] - Gene

Summary

Official Symbol: F2provided by HGNC
Official Full Name: coagulation factor II, thrombinprovided by HGNC
Primary source: HGNC:HGNC:3535
See related: Ensembl:ENSG00000180210 MIM:176930; Vega:OTTHUMG00000150344
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PT; THPH1; RPRGL2
Summary: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression: Restricted expression toward liver (RPKM 385.8) See more
Orthologs: mouse all

Genomic context

Location:: 11p11.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	11	NC_000011.10 (46719166..46739508)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (46740743..46761056)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.
Title: Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses.
Prothrombin gene mutation is rare in Budd-Chiari syndrome patients in India.
Title: Prothrombin gene mutation in Budd-Chiari syndrome-The first case report from India.
In HBV-related cirrhosis, the combination of miR-122, AFP and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Title: Risk of hepatocellular carcinoma in HBV cirrhotic patients assessed by the combination of miR-122, AFP and PIVKA-II.
Data, including data using network analysis, suggest that angiotensinogen (AGT), mitogen-activated protein kinase-14 (MAPK14), and prothrombin (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
Title: Proteomics and bioinformatics analysis of altered protein expression in the placental villous tissue from early recurrent miscarriage patients.
Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin inhibition.
Title: Screening and functional exploration of prothrombin Arg596 related mutations in Chinese venous thromboembolism patients.
The induction of TG by BXPC3 cells was mainly driven by the TF pathway while TG generation triggered by MCF7 cells was also driven by FXII activation.
Title: Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells.
we were not able to confirm the association between the polymorphisms of f5, f2, and mthfr and pregnancy loss in Bosnian women
Title: Prevalence of F5 1691G>A, F2 20210G>A, and MTHFR 677C>T polymorphisms in Bosnian women with pregnancy loss.
Platelets were activated in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients, and such activation was at least partially attributed to the thrombin-protease-activated receptors (PARs) pathway.
Title: Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway.
The meta-analysis enabled us to underline the importance of DCP in the refinement of the eligibility criteria of hepatocellular cancer (HCC)patients for liver transplant (LT). This information, based on Japanese studies performed in the setting of living-donor LT only, needs further validation in the Western world both in the setting of post-mortem and living-donor LT.
Title: Des-gamma-carboxy prothrombin in hepatocellular cancer patients waiting for liver transplant: a systematic review and meta-analysis.
HCC [hepatocellular carcinoma] patients who are sero-positive for DCP [Des-gamma-carboxyprothrombin] and sero-negative for AFP[Alpha-fetoprotein] have significantly higher levels of serum ALT[alanine aminotransferase]; serum ALT levels may be of diagnostic importance in AFP-negative, HBV-related HCC [hepatitis B virus-related hepatocellular carcinoma] patients.
Title: Diagnostic utility of alpha-fetoprotein and des-gamma-carboxyprothrombin in nigerians with hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (691)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Ischemic stroke MedGen: C0948008 OMIM: 601367 GeneReviews: Not available	Compare labs
Pregnancy loss, recurrent, susceptibility to, 2 MedGen: C3280672 OMIM: 614390 GeneReviews: Not available	Compare labs
Prothrombin deficiency, congenital MedGen: C0020640 OMIM: 613679 GeneReviews: Not available	Compare labs
VENOUS THROMBOSIS MedGen: C0398623 OMIM: 188050 GeneReviews: Prothrombin-Related Thrombophilia	Compare labs

NHGRI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Biological, clinical and population relevance of 95 loci for blood lipids. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Discovery and refinement of loci associated with lipid levels. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of coagulation factor II (prothrombin; F2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Thrombin activates HIV-1 gp120/gp41 and enhances virus-cell fusion	PubMed
	env	Cleavage at amino acid position R315 of HIV-1 gp120 by thrombin is enhanced by soluble CD4 binding	PubMed
Envelope surface glycoprotein gp160, precursor	env	Thrombin enhances the fusion mediated by two R5-tropic HIV-1 gp160	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
Angiopoietin receptor Tie2-mediated signaling
Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...
Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
Common Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
Common Pathway of Fibrin Clot Formation, organism-specific biosystemThe common pathway consists of the cascade of activation events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the f...
Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
Complement and Coagulation Cascades, organism-specific biosystemBlood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the for...
Complement and coagulation cascades, organism-specific biosystem (from KEGG)
Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Complement and coagulation cascades, conserved biosystem (from KEGG)
Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem (from Pathway Interaction Database)
FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem
FOXA2 and FOXA3 transcription factor networks
Folate Metabolism, organism-specific biosystem (from WikiPathways)
Folate Metabolism, organism-specific biosystem
Folate Metabolism
Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME)
Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystemThe formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to ...
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem (from REACTOME)
Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
Gamma-carboxylation of protein precursors, organism-specific biosystem (from REACTOME)
Gamma-carboxylation of protein precursors, organism-specific biosystemGamma-carboxylation of a cluster of glutamate residues near the amino termini of thrombin, factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas 6 is required for these proteins t...
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, organism-specific biosystem (from REACTOME)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, organism-specific biosystemA number of proteins, including eight required for normal blood clot formation and its regulation (Prothrombin (factor II), factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas6)...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
IL1 and megakaryocytes in obesity, organism-specific biosystem (from WikiPathways)
IL1 and megakaryocytes in obesity, organism-specific biosystemSchematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory a...
Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystemThe intrinsic pathway of blood clotting connects interactions among kininogen (high molecular weight kininogen, HK), prekallikrein (PK), and factor XII to the activation of clotting factor X by a ser...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
Platelet Aggregation (Plug Formation), organism-specific biosystemThe tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment o...
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem (from REACTOME)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystemThe family of Insulin like Growth Factor Binding Proteins (IGFBPs) share 50% amino acid identity with conserved N terminal and C terminal regions responsible for binding Insulin like Growth Factors I...
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Removal of aminoterminal propeptides from gamma-carboxylated proteins, organism-specific biosystem (from REACTOME)
Removal of aminoterminal propeptides from gamma-carboxylated proteins, organism-specific biosystemFurin is an endopeptidase localized to the Golgi membrane that cleaves many proteins on the carboxyterminal side of the sequence motif Arg-[any residue]-(Lys or Arg)-Arg (Jones et al. 1995; Leduc et ...
Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
Selenium Micronutrient Network, organism-specific biosystem
Selenium Micronutrient Network
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-4-mediated signaling events, organism-specific biosystem
Syndecan-4-mediated signaling events
Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystem (from REACTOME)
Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystemThrombin activates proteinase activated receptors (PARs) that signal through heterotrimeric G proteins of the G12/13 and Gq families, thereby connecting to a host of intracellular signaling pathways....
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, organism-specific biosystem (from REACTOME)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, organism-specific biosystemGamma-carboxylated proteins are moved by anterograde transport from the endoplasmic reticulum to the Golgi apparatus (Kirchhausen 2000).
Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
Vitamin B12 Metabolism, organism-specific biosystem
Vitamin B12 Metabolism

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-W73782 (e-PCR)
- UniSTS:40758

RH80273 (e-PCR)
- UniSTS:89656

STS-H75495 (e-PCR)
- UniSTS:32672

GDB:196314 (e-PCR)
- UniSTS:155825

GDB:196315 (e-PCR)
- UniSTS:155826

RH17520 (e-PCR)
- UniSTS:479

Homology

Homologs of the F2 gene: The F2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 233 organisms have orthologs with human gene F2
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
enzyme activator activity	IEA Inferred from Electronic Annotation more info
growth factor activity	TAS Traceable Author Statement more info	PubMed
heparin binding	IDA Inferred from Direct Assay more info	PubMed
lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
serine-type endopeptidase activity	TAS Traceable Author Statement more info
signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
thrombospondin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
ER to Golgi vesicle-mediated transport	TAS Traceable Author Statement more info
G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
acute-phase response	IEA Inferred from Electronic Annotation more info
antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
blood coagulation	TAS Traceable Author Statement more info
blood coagulation, intrinsic pathway	TAS Traceable Author Statement more info
cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cellular protein metabolic process	TAS Traceable Author Statement more info
cytolysis by host of symbiont cells	IDA Inferred from Direct Assay more info	PubMed
fibrinolysis	IDA Inferred from Direct Assay more info	PubMed
multicellular organism development	TAS Traceable Author Statement more info	PubMed
negative regulation of astrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
negative regulation of fibrinolysis	TAS Traceable Author Statement more info	PubMed
negative regulation of platelet activation	TAS Traceable Author Statement more info	PubMed
negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
neutrophil mediated killing of gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
platelet activation	IDA Inferred from Direct Assay more info	PubMed
platelet activation	TAS Traceable Author Statement more info
positive regulation of JAK-STAT cascade	NAS Non-traceable Author Statement more info	PubMed
positive regulation of blood coagulation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of lipid kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase signaling	IEA Inferred from Electronic Annotation more info
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IEA Inferred from Electronic Annotation more info
regulation of blood coagulation	TAS Traceable Author Statement more info	PubMed
regulation of cell shape	IEA Inferred from Electronic Annotation more info
regulation of complement activation	TAS Traceable Author Statement more info
regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
regulation of signaling receptor activity	IEA Inferred from Electronic Annotation more info
response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi lumen	TAS Traceable Author Statement more info
blood microparticle	HDA more info	PubMed
endoplasmic reticulum lumen	TAS Traceable Author Statement more info
colocalizes_with external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	HDA more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	HDA more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: prothrombin

Names: prepro-coagulation factor II; prothrombin B-chain; serine protease; thrombin factor II

NP_000497.1

EC 3.4.21.5

NP_001298186.1

EC 3.4.21.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008953.1 RefSeqGene

Range

4974..25316

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_551

mRNA and Protein(s)

NM_000506.4 → NP_000497.1 prothrombin isoform 1 preproprotein

See identical proteins and their annotated locations for NP_000497.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK303747, AK312965, BC051332, DA638868

Consensus CDS

CCDS31476.1

UniProtKB/Swiss-Prot

P00734

Related

ENSP00000308541.5, OTTHUMP00000197117, ENST00000311907.9, OTTHUMT00000317706

Conserved Domains (6) summary

smart00020
Location:363 → 613

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:25 → 88

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

smart00130
Location:211 → 293

KR; Kringle domain

cd00108
Location:105 → 186

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:364 → 616

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09396
Location:317 → 363

Thrombin_light; Thrombin light chain
NM_001311257.1 → NP_001298186.1 prothrombin isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AK303747, AK312965, BC051332, DA638868

UniProtKB/Swiss-Prot

P00734

Conserved Domains (6) summary

smart00020
Location:347 → 597

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:11 → 72

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

smart00130
Location:195 → 277

KR; Kringle domain

cd00108
Location:89 → 170

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:348 → 600

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09396
Location:301 → 347

Thrombin_light; Thrombin light chain