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ITK IL2 inducible T cell kinase [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100599482, updated on 8-Mar-2024

Summary

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Gene symbol
ITK
Gene description
IL2 inducible T cell kinase
See related
EnsemblRapid:ENSNLEG00000003943
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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See ITK in Genome Data Viewer
Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 2 NC_044382.1 (21554952..21630105, complement)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 2 NC_019817.1 (23803245..23878539, complement)

Chromosome 2 - NC_044382.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L26 pseudogene Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene fibronectin type III domain containing 9 Neighboring gene golgi associated RAB2 interactor family member 3 Neighboring gene mediator complex subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in NK T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase ITK/TSK

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044382.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    21554952..21630105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003268572.3 → XP_003268620.2  tyrosine-protein kinase ITK/TSK

    UniProtKB/TrEMBL
    G1QV28
    Related
    ENSNLEP00000004798.2, ENSNLET00000005046.3
    Conserved Domains (4) summary
    cd05112
    Location:358 → 613
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:232 → 340
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:174 → 229
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
Nucleotide Protein
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