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ITK IL2 inducible T cell kinase [ Homo sapiens (human) ]

Gene ID: 3702, updated on 28-Jun-2020

Summary

Official Symbol
ITKprovided by HGNC
Official Full Name
IL2 inducible T cell kinaseprovided by HGNC
Primary source
HGNC:HGNC:6171
See related
Ensembl:ENSG00000113263 MIM:186973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMT; LYK; LPFS1; PSCTK2
Summary
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 23.9), appendix (RPKM 14.7) and 9 other tissues See more
Orthologs

Genomic context

See ITK in Genome Data Viewer
Location:
5q33.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (157180840..157255185)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156607907..156682109)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 7 Neighboring gene family with sequence similarity 71 member B Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene uncharacterized LOC102724404 Neighboring gene fibronectin type III domain containing 9 Neighboring gene ribosomal protein L26 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Lymphoproliferative syndrome 1
MedGen: C3552634 OMIM: 613011 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of personality traits in bipolar patients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Inducible T-cell kinase (ITK) affects viral entry and gp120-induced actin reorganization, but does not affect HIV-1 reverse transcription or proviral DNA integration PubMed
Nef nef HIV-1 Nef alleles from representative M-group HIV-1 subtypes can interact with ITK. Selective ITK inhibitor blocks HIV-1 infectivity and replication in a Nef-dependent manner PubMed
nef A cell-based bimolecular fluorescence complementation assay demonstrates that HIV-1 Nef interacts with the Tec family members Bmx, Btk, and Itk, but not with Tec or Txk in 293T cells PubMed
Pr55(Gag) gag Tec kinase chemical inhibitors diminish the recruitment of ITK to the plasma membrane perturbing HIV-1 Gag-ITK co-localization, disrupting F-actin polymerization, and inhibiting HIV-1 release and replication PubMed
gag HIV-1 Gag, ITK, and F-actin are located in overlapping and discrete regions of T cell-T cell contact sites PubMed
gag HIV-1 Gag and ITK are present at regions that contain cholera toxin B in HIV-1 infected T cells, indicating that Gag and ITK co-localize in lipid raft microdomains PubMed
gag HIV-1 Gag co-localizes with IL2-inducible T-cell kinase (ITK) at the plasma membrane of transfected HEK293T cells and HIV-1 infected T cells PubMed
gag ITK is required for efficient transcription from the HIV-1 LTR, induces a modest increase in Gag expression, and enhances virion production PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126257, MGC126258

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
NK T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell activation TAS
Traceable Author Statement
more info
PubMed 
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
gamma-delta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tyrosine-protein kinase ITK/TSK
Names
IL-2-inducible T-cell kinase
T-cell-specific kinase
homolog of mouse T-cell itk/tsk
interleukin-2-inducible T-cell kinase
kinase EMT
tyrosine-protein kinase LYK
NP_005537.3
XP_016864932.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016276.1 RefSeqGene

    Range
    5001..79203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_189

mRNA and Protein(s)

  1. NM_005546.4NP_005537.3  tyrosine-protein kinase ITK/TSK

    See identical proteins and their annotated locations for NP_005537.3

    Status: REVIEWED

    Source sequence(s)
    AC010609, BX538196, D13720, DB150488
    Consensus CDS
    CCDS4336.1
    UniProtKB/Swiss-Prot
    Q08881
    Related
    ENSP00000398655.3, ENST00000422843.7
    Conserved Domains (4) summary
    cd05112
    Location:358613
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:232340
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:174229
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    157180840..157255185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009443.1XP_016864932.1  tyrosine-protein kinase ITK/TSK isoform X1

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